Conor Murray and Keith Earls will make their first Munster appearances since the Rugby World Cup after being named in Anthony Foley's starting line-up to face Edinburgh at Murrayfield on Saturday.
The head coach makes eight changes to the starting XV that defeated Ulster at Thomond Park for the Pro12 Round 7 clash, kick-off 5.15pm.
An all new front row sees Dave Kilcoyne and Duncan Casey come back in with John Ryan making his first start of the season. Donnacha Ryan is another to make his first Munster start of the season and does so partnering Dave Foley in the second row.
Dave O'Callaghan returns at six with Jack O'Donoghue continuing at seven and captain CJ Stander completes the back row in switching back to number eight.
Half-backs Conor Murray and Ian Keatley resume their partnership for the first time this season with Francis Saili and Keith Earls forming a new pairing in the midfield.
The only personnel change amongst the back-three sees winger Ronan O'Mahony make his first start of the current campaign. Gerhard van den Heever remains on the right wing and Simon Zebo makes the move to full-back.
Uruguayan international Mario Sagario is in line to make his first appearance for the province after being named amongst the replacements.
Munster: Simon Zebo; Gerhard van den Heever, Keith Earls, Francis Saili, Ronan O'Mahony; Ian Keatley, Conor Murray; Dave Kilcoyne, Duncan Casey, John Ryan; Donnacha Ryan, Dave Foley; Dave O'Callaghan, Jack O'Donoghue, CJ Stander (captain).
Replacements: Niall Scannell, James Cronin, Mario Sagario, Robin Copeland, Jordan Coghlan, Tomás O'Leary, Rory Scannell, Denis Hurley.
Rory Best and Ruan Pienaar are named on the bench ahead of Ulster's trip to face Newport Gwent Dragons at Rodney Parade this Sunday at 2.30pm.
Head coach Les Kiss has made four personnel changes and three positional changes to the team that lost narrowly to Munster last weekend.
Peter Nelson returns to the side at fullback and is joined in the back three by Sammy Arnold and Rory Scholes, who replaces an injured Andrew Trimble. Paul Marshall and Stuart McCloskey are retained at scrum-half and inside centre respectively.
Up front Kyle McCall comes into the team to replace Andrew Warwick at loosehead prop, joining acting captain Rob Herring and Wiehahn Herbst in the front row.
Dan Tuohy packs down with Franco van der Merwe in the second row, with Stephen Mulholland, who will be making his Ulster debut, named alongside Chris Henry and Robbie Diack in the back row.
Diack returns to the starting line up having recovered from a muscle tear in his thigh sustained against Treviso on October 2nd.
Ulster skipper, Best, will play his first game for the province since May if, as expected, he comes off the bench
He is named alongside front row cover Ricky Lutton and Bronson Ross. Lewis Stevenson and Sean Reidy are named as forward replacements and World Cup semi-finalist Pienaar is named with Ian Humphreys and Craig Gilroy as backline cover.
Ulster enter the game in fifth place in the Guinness PRO12 league with 18 points - three places ahead of Sunday's opponents.
Ulster: Peter Nelson, Rory Scholes, Darren Cave, Stuart McCloskey, Sammy Arnold, Paddy Jackson, Paul Marshall; (1-8) Kyle McCall, Rob Herring (captain), Wiehahn Herbst, Dan Tuohy, Franco van der Merwe, Robbie Diack, Chris Henry, Stephen Mulholland.
Replacements: Rory Best, Ricky Lutton, Bronson Ross, Lewis Stevenson, Sean Reidy, Ruan Pienaar, Ian Humphreys, Craig Gilroy.
Ireland international Robbie Henshaw will start in the full-back position for Connacht's Pro12 Friday night clash with Benetton Treviso at the Sportsground, kick off 7:30pm.
The 22-year-old, in his first appearance for Connacht since the Rugby World Cup, is one of six personnel changes to Pat Lam's side from last Saturday's win over Edinburgh.
Last week's man of the match Tiernan O'Halloran shifts to right wing in a slightly changed back line that also sees scrum-half John Cooney come in for his second start of the season.
In the pack, Dave Heffernan and Ireland international Nathan White are introduced to the front row, while Ultan Dillane comes in to partner Andrew Browne, playing his 100th Pro12 game, in the second row.
Galway man Eoin McKeon returns to the back row to link up with captain John Muldoon and the season's top try scorer Nepia Fox-Matamua.
From the bench, USA international out-half AJ MacGinty could make his first appearance in a Connacht jersey, after the Dubliner joined the province last month.
Commenting on the team selection and the upcoming game, head coach Pat Lam said: "We've made a few changes this week, with Robbie and Nathan back for us but also some guys returning from injury. This is only game four of the 16-game run so it's a long way to go and we're going to need players feeling as fresh as possible each week.
"Robbie will start in the 15 shirt for us where he has a lot of experience from his earlier days at Connacht. Obviously Tiernan has done a great job for us at fullback since the start of the season but his move to wing for this game means we can keep that continuity in our centre partnership for this week."
Connacht: Robbie Henshaw, Tiernan O'Halloran, Bundee Aki, Craig Ronaldson, Matt Healy, Jack Carty, John Cooney, Denis Buckley, Dave Heffernan, Nathan White, Ultan Dillane, Andrew Browne, John Muldoon (captain), Nepia Fox-Matamua, Eoin McKeon
Replacements: Tom McCartney, Finlay Bealham, Rodney Ah You, Aly Muldowney, Eoghan Masterson, Kieran Marmion, AJ MacGinty, Darragh Leader
Leinster head coach Leo Cullen has named a totally changed team to take on Scarlets in the RDS on Friday, kick-off 7.35, as his international stars return to provincial duty.
In what is a completely new starting XV from the one that faced Treviso last Sunday and there is a first start for Leinster for Lansdowne's Cian Kelleher on the left wing and for James Tracy at hooker, while UCD's Garry Ringrose also gets a first start in the centre having previously started all his games on the wing.
There is also the return of a number of internationals who were away during the Rugby World Cup.
Rob Kearney starts in Leinster colours for the first time this season have played four games during the World Cup, scoring three tries in the process.
He is joined in the back three by fellow returnee Zane Kirchner who was part of the South Africa squad that secured a third placed finish in England. Kelleher, on the left wing, has made three appearances this season from the bench having made his debut in last season's game away to Edinburgh.
In the centre Noel Reid and Garry Ringrose form a new look partnership, while in the half backs Isaac Boss starts with Ian Madigan again making his seasonal bow from 10.
A completely new pack sees UCD's James Tracy make a first start for the province at hooker.
Leinster: Rob Kearney, Zane Kirchner, Garry Ringrose, Noel Reid, Cian Kelleher, Ian Madigan, Isaac Boss, Cian Healy, James Tracy, Mike Ross, Devin Toner, Tom Denton, Dominic Ryan, Sean O'Brien Jamie Heaslip
Replacements: Bryan Byrne, Jack McGrath, Marty Moore, Hayden Triggs, Dan Leavy, Luke McGrath, Johnny Sexton, Ben Te'o