Scrum-half Greig Laidlaw will start for Scotland against Ireland in Sunday's World Cup Pool A clash.
The experienced Clermont player got the nod over Ali Price for the number nine berth.
In all there are 10 changes to the side that beat Georgia two weeks ago
Elsewhere, Finn Russell and Stuart Hogg take their spots at out-half and full-back respectively.
Stuart McInally captains Gregor Townsend's team from hooker, with Allan Del and Willem Nel on either side.
Grant Gilchrist and Jonny Gray form the second row, while John Barclay, Hamish Watson and Ryan Wilson, at number eight, make up the back row.
Sam Johnson and Duncan Taylor are in the centre with the wing positions filled by Sean Maitland and Tommy Seymour.
TEAM ANNOUNCEMENT— Scottish Rugby (@Scotlandteam) September 20, 2019
Your Scotland team to play Ireland in this Sunday's Rugby World Cup Pool A opener in Yokohama has been announced!
Kick-off 4.45pm local time, 8.45am BST - Live on ITV#AsOne #RWC2019 pic.twitter.com/YcooIYciQ6
At the Ireland team announcement Joe Schmidt had named-checked Laidlaw as a valuable tool for the Scots, especially in the event of inclement weather.
"He's a very proficient kicker, he’s a very effective goal-kicker as well," he said.
"When it does rain, points become just that little bit more valuable because they are harder to get because it’s harder to sustain continuity of play. Therefore, Greig Laidlaw could be very useful for them."
Townsend told the Scottish Rugby website: "In Ireland we face a quality opposition who, over the past number of years, have earned the right to be the number one ranked side in the world.
"We know them well and are well aware of the strengths they possess throughout their squad. We expect them to play very well, as they did in their most recent games against Wales, so only our best performance will do in order to win.
"The prospect of facing them in the opening round of a Rugby World Cup is a fantastic challenge for our players and supporters around the world.
Scotland: Stuart Hogg, Tommy Seymour, Duncan Taylor, Sam Johnson, Sean Maitland, Finn Russell, Greig Laidlaw; Allan Dell, Stuart McInally, (capt), Willem Nel, Grant Gilchrist, Jonny Gray, John Barclay, Hamish Watson, Ryan Wilson.
Replacements: Fraser Brown, Gordon Reid, Simon Berghan, Scott Cummings, Blade Thomson, Ali Price, Chris Harris, Darcy Graham.