Wei Ling Hsu clinched a two-shot victory at the Pure Silk Championship in Williamsburg, Virginia.
The Chinese Taipei golfer, who shared the overnight lead on 10-under with Moriya Jutanugarn after round three, picked up three shots overall to finish on 13-under with a 68.
Thailand's Jutanugarn was runner-up after carding a 70 to finish on 11-under, one shot clear of USA's Jennifer Korda.
Stephanie Meadow finished in a tie for 48th, slipping back down the leaderboard after carding a final-round 76.
The Co Antrim native bogeyed the second before dropping three shots in a row on the seventh, eighth and ninth.
Further bogeys followed on 11 and 14 before she finished on a more positive note with a birdie on 17.