Tyrone joint manager Brian Dooher described Mayo's penalty miss as a "big game-changer" and paid tribute to the Red Hand defence, which kept the Westerners goalless.
Ryan O'Donoghue's miss came five minutes before Cathal McShane's goal, which gave the Ulster champions a cushion they would retain to the final whistle, as they won out 2-14 to 0-15 in the All-Ireland final.
"It was tight at times and probably the penalty was the big turning point in the game for us," said Dooher.
"The boys put in real effort and dug deep, [gave] everything they had to give, and in the end it got us over the line."
He told RTÉ Sport: "The penalty was a big game-changer. We were under pressure at that time and Mayo were coming strong at us and they had a few other goal chances as well, but thankfully we repelled them.
"The defence held up again, the defence has been outstanding this year."
Dooher was asked to reflect on a 2021 season, which saw himself and co-manager Feargal Logan cast in at the deep end - shipping six goals to Kerry in the league, coming past Cavan, Donegal and Monaghan in Ulster before almost conceding their Kerry semi-final due to an outbreak of Covid.
"It's definitely been a rollercoaster of a season. We packed everything into the space of two or three months there," said Dooher, who described their final showing as a "hardworking rather than exceptional performance".
"We had a two-week turnaround there and we have an exceptional analysis team, who dug up all the information we needed to get our match-ups right, but it's a whole team effort."
On his relationship with Logan, he said: "We probably don't take each other too seriously. We bounce comments off each other and we have a fairly good relationship."
Man of the match Darren McCurry reflected on his own journey, which saw him leave the panel in 2018 to scoring 1-04 in an All-Ireland final.
"When I left in 2018, I just had to get myself back to my best, back to 'Dazzler' and I think I did that and I think I showed that today. I'm back enjoying my football and it's just such an unbelievable feeling on All-Ireland final day just taking it all in."
"When I left in 2018, I just had to get back to my best, back to Dazzler..."— The Sunday Game (@TheSundayGame) September 11, 2021
Man of the Match Darren McCurry on his journey to becoming an All-Ireland champion #RTEGAA #TYRONEGAA pic.twitter.com/1I2NMLii2a