Kevin Walsh will give three Galway men their first taste of senior championship football in the cauldron of a Connacht SFC quarter-final against Mayo in Castlebar on Sunday.
Seán Andy Ó Ceallaigh starts in the full-back line, Ciaran Duggan lines up in the middle of the field and Barry McHugh has been selected top of the left.
Gary O'Donnell, Tom Flynn and Seán Armstrong replace Sean Kelly, Eamonn Brannigan and Peter Cooke as Walsh shakes up the 15 who started the Allianz Football League final defeat to Dublin.
Meanwhile Cillian O'Connor will start for Mayo. The two-time Young Footballer of the Year was pegged as an injury doubt after hobbling off in Mayo's penultimate league game against Tyrone and subsequently missed their dramatic draw with Donegal in Ballybofey.
However, he's recovered in time and has been named as captain for this weekend's game.
He's joined in the full-forward line by Conor Loftus, the highly rated 2013 All-Ireland minor winner, who has typically been deployed as a sub until now.
Altogether, the starting XV contains five changes from the team which started last year's All-Ireland final. Ger Cafferkey returns to the full-back berth while manager Stephen Rochford has handed a championship debut to Belmullet's Eoin O'Donoghue at corner back.
Chris Barrett, Brendan Harrison, Donal Vaughan, Jason Doherty and Lee Keegan are the players missing from the side which ran Dublin to a point in last year's All-Ireland final, with Keegan's absence long flagged through injury.
Galway: Ruairi Lavelle; Declan Kyne, Seán Andy Ó Ceallaigh, Eoghan Kerin; Gary O'Donnell, Gareth Bradshaw, Cathal Sweeney; Tom Flynn, Cathal Duggan; Shane Walsh, Paul Conroy, Johnny Heaney; Sean Armstrong, Damien Comer, Barry McHugh
Mayo: David Clarke; Eoin O'Donoghue, Ger Cafferkey, Keith Higgins; Patrick Durcan, Colm Boyle, Stephen Coen; Seamus O'Shea, Tom Parsons; Kevin McLoughlin, Aidan O'Shea, Diarmuid O'Connor; Conor Loftus, Cillian O'Connor, Andy Moran.
Gary Walsh is one of four changes to the Laois team named by John Sugrue for Saturday's Leinster SFC opener against Wexford.
The Ballylinan man is named at corner-forward, alongside David Conway, with Damien O'Connor also coming into the forward line. Brian Glynn, Benny Carroll and Eoin Lowry (injured) make way.
In defence, Ruaidhrí Fennell replaces Robbie Piggott, after the corner-back made the decision to spend the summer in the United States.
Walsh was dropped for the Allianz League Division 4 final victory over Carlow after sending a controversial - and subsequently deleted tweet - regarding the verdict in the trial of Paddy Jackson, Stuart Olding, Blane McIlroy and Rory Harrison.
BREAKING: Senior Football starting 15 to face Wexford in Saturday's Leinster SFC game is announced. pic.twitter.com/yu6f4OOnFt— Laois GAA (@CLGLaois) May 9, 2018
Making their championship bows for Wexford against the O'Moore County are wing-backs Glen Malone (Shelmaliers) and Shane Doyle (Ballyhogue) and full-forward Nick Doyle (Starlights).
Laois: Graham Brody; Ruaidhri C Fennell, Mark Timmons, Gareth Dillon; Trevor Collins, Colm Begley, Stephen Attride; John O’Loughlin, Kieran Lillis; Alan Farrell, Donal Kingston, Damien O’Connor; Ross Munnelly, David Conway, Gary Walsh.
Wexford: Conor Swaine; Michael Furlong, Jim Rossiter, Conor Carty; Glen Malone, Naomhan Rossiter, Shane Doyle; Brian Malone, Daithi Waters; James Stafford, Eoghan Nolan, Ben Brosnan; Paul Curtis, Nick Doyle, Donal Shanley.
Cavan manager Mattie McGleenan has named four debutants in his team for Sunday's Ulster opener against Donegal in Ballybofey.
Bryan Magee starts in midfield, while Oisin Kiernan and Enda Flanagan also make their senior championship in the half-forward line.
Conor Bradley is the last debutant, with the Ramor United man being named at left corner-forward.
Dara McVeety is a notable absentee after picking up a hamstring injury in the Division 2 final loss to Roscommon.
Cavan: Raymond Galligan; Jason McLoughlin, Padraig Faulkner, Niall Murray, Martin Reilly, Ciaran Brady, Conor Moynagh, Killian Clarke, Bryan Magee; Cian Mackey, Oisin Kiernan, Enda Flanagan; Caoimhin O'Reilly, Gearoid McKiernan, Conor Bradley
Follow Offaly v Galway this Saturday via our live blog on RTÉ.ie and the News Now App or listen to exclusive national radio commentary on RTÉ Radio 1. Highlights on the Sunday Game on RTÉ2, 9.30pm.