World leaders are arriving in New York for the 80th session of the UN General Assembly, among them Taoiseach Micheál Martin and Tánaiste Simon Harris.
The week's events are expected to be dominated by discussion of the ongoing wars in Ukraine and Gaza.
Today, a conference on the two-state solution for Israel and Palestine will take place, where more UN member states are due to recognise the State of Palestine.
High-level weeks kick off this morning with a UN Security Council meeting on the incursion of Russian fighter jets into Estonian airspace - putting the war in Ukraine at the top of the agenda.
Then, at this afternoon’s conference on the two-state solution, several European countries including France, Belgium, Malta and Luxembourg are set to recognise the state of Palestine, following yesterday’s declarations by the UK, Canada, Australia and Portugal.
The United States and Israel firmly oppose the move, calling Palestinian recognition a reward for terror.
The US State Department denied visas to Palestinian delegates due to travel to New York, citing national security reasons.
The President of the Palestinian Authority Mahmoud Abbas will address the conference via a pre-recorded video.
Speaking to reporters on arrival in New York, the Tánaiste said it was "outrageous" that the Palestinian Authority were not allowed to attend and called it an "extraordinarily dangerous precedent".