Israel's military pounded Gaza City prior to a planned takeover, with another 123 people killed in the last day according to the Gaza health ministry, while militant group Hamas held further talks with Egyptian mediators.
The 24-hour death toll was the worst in a week as Israeli Prime Minister Benjamin Netanyahu reiterated an idea that Palestinians should simply leave the territory.
"They're not being pushed out, they’ll be allowed to exit," he told Israeli television channel i24NEWS.
"All those who are concerned for the Palestinians and say they want to help the Palestinians should open their gates and stop lecturing us."
Israel's planned re-seizure of Gaza City - which it took in the early days of the war before withdrawing - is probably weeks away, officials say.
Israeli planes and tanks bombed eastern areas of Gaza City heavily, residents said, with many homes destroyed in the Zeitoun and Shejaia neighbourhoods overnight. Al-Ahli hospital said 12 people were killed in an airstrike on a home in Zeitoun.
Tanks also destroyed several houses in the east of Khan Younis in south Gaza too, while in the centre Israeli gunfire killed nine people seeking aid in two separate incidents, Palestinian medics said.
Eight more people, including three children, have died of starvation and malnutrition in Gaza in the past 24 hours, the territory's Hamas run health ministry said.
That took the total to 235, including 106 children, since the war began.
Israel disputes the malnutrition and hunger figures reported by the health ministry.
Hamas chief negotiator Khalil Al-Hayya's meetings with Egyptian officials in Cairo on Wednesday were to focus on stopping the war, delivering aid and "ending the suffering of our people in Gaza," Hamas official Taher al-Nono said in a statement.
Egyptian security sources said the talks would also discuss the possibility of a comprehensive ceasefire that would see Hamas relinquish governance in Gaza and concede its weapons.
A Hamas official said the group was open to all ideas if Israel ends the war and pulls out. However, "laying down arms before the occupation is dismissed is impossible," the official, who asked not to be named, said.
Mr Netanyahu's plan to expand military control over Gaza, which Israeli sources said could be launched in October, has heightened global outcry over the widespread devastation, displacement and hunger in the territory.
Twenty-four nations this week decried the "unimaginable levels" of suffering and urged Israel to allow unrestricted aid.
Israel accuses Hamas of stealing aid and says it has taken steps to increase supplies, including daily combat pauses in some areas and protected routes for convoys.
The Israeli military said that nearly 320 trucks entered Gaza through the Kerem Shalom and Zikim crossings and that a further nearly 320 trucks were collected and distributed by the UN and international organisations in the past 24 hours along with three tankers of fuel and 97 pallets of air-dropped aid.
But the UN and Palestinians say aid remains far from sufficient.
The war began on 7 October 2023, when Hamas-led militants stormed into southern Israel, killing 1,200 people and taking 251 hostages, according to Israeli figures.
Israel's offensive against Hamas in Gaza since then has killed more than 61,000 Palestinians, according to local health officials.
Arab states and much of the international community want post-war Gaza to be governed by the Palestinian Authority, which exercises limited governance in the Israeli-occupied West Bank.
We need your consent to load this rte-player contentWe use rte-player to manage extra content that can set cookies on your device and collect data about your activity. Please review their details and accept them to load the content.Manage Preferences
The authority's foreign minister, Varsen Aghabekian Shahin, told reporters it was ready to assume full responsibility in Gaza. Hamas would have no role and be required to hand over arms, she added, calling for an international peacekeeping force and withdrawal by Israel.
Hamas says it is ready to quit Gaza governance for a non-partisan technocratic entity agreed by all Palestinian parties.
Israel says it does not trust the PA to rule Gaza.
