At least 42 people have been injured during clashes between Palestinians and Israeli police at Jerusalem's Al-Aqsa Mosque - Islam's third-holiest site - the Palestinian Red Crescent said.
Israeli police said they intervened when hundreds of people began hurling rocks and fireworks, including in the direction of the Western Wall, where Jewish worshippers gather.
Police fired rubber bullets and stun grenades during the clashes.
None of the injuries were serious, the Red Crescent said, adding that 22 people had been taken to hospital.
There were almost daily confrontations at the mosque this month when Ramadan overlapped with the Jewish celebration of Passover, which brought hundreds of thousands of Muslims and Jews to the heavily policed compound in the old city.
However, the violence had abated this week following the end of Passover and after Israel halted Jewish visits to the huge esplanade which is home to the gilded 7th-century Dome of the Rock and the 8th-century Al-Aqsa mosque.
Ramadan ends next week and the final Friday of the fasting month often sees especially large crowds gather at Al-Aqsa.
Israeli officials have blamed tensions this month on Islamist groups, including Hamas, which rules Gaza, saying they have encouraged youths to stage riots aimed at stirring anger in the Muslim world against Israel.
Palestinians accused Israel of not doing enough to enforce a long-standing ban on Jewish prayer on the esplanade. Israel rejects this accusation.
Al-Aqsa compound sits atop the Old City plateau of East Jerusalem, which Israel captured in the 1967 Middle East war and annexed in a move that has not won international recognition.
Palestinians want East Jerusalem to be the capital of a state they seek to establish in the occupied West Bank and Gaza.