Hundreds of mourners joined an emotional memorial service in Minneapolis yesterday for George Floyd, as civil rights leader Al Sharpton vowed mass protests will continue until "we change the whole system of justice".
Largely peaceful demonstrations took place later in cities from coast to coast.
In New York, thousands marched over Brooklyn Bridge, while in Washington and Los Angeles curfews were lifted and crowds reduced.
In Minneapolis, Mr Floyd's attorney told mourners he would find justice for the 46-year-old, who died during a 25 May arrest when a white police officer knelt on his neck for nearly nine minutes.
"It was not the coronavirus pandemic that killed George Floyd," said Benjamin Crump, who is representing Mr Floyd's family. "It was that other pandemic. The pandemic of racism and discrimination."
The crowd stood in silence for eight minutes and 46 seconds - the same length of time that officer Derek Chauvin spent with his knee on Mr Floyd's neck, a scene captured on video.
Mr Floyd's death has reignited long-felt anger over police killings of African-Americans and unleashed a nationwide wave of civil unrest unlike any seen in the US since Martin Luther King Jr's 1968 assassination.
With marches for racial justice stretching beyond the US and around the world, Al Sharpton said Mr Floyd's death would not be in vain.
"It's time for us to stand up in George's name and say get your knee off our necks," said the 65-year-old Baptist minister.
"You changed the world, George," he said. "We're going to keep fighting, George."
"We're going to keep going until we change the whole system of justice."
Members of Mr Floyd's family were among several hundred people attending the North Central University service.
Minneapolis police chief Medaria Arradondo dropped to a knee as the hearse bearing Mr Floyd's remains arrived for the service.
'Necessary and overdue'
A vigil for Mr Floyd was also held in New York and was attended by thousands of people, including Mr Floyd's brother, Terrence.
"White Silence is Violence," a sign read. "Make America Not Embarrassing Again," read another.
Arrests were reported in Manhattan after the 8pm curfew passed, while upstate in Buffalo, a police officer who pushed an elderly protester to the ground drew outrage as footage was shared widely online.
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A police statement said the man, who appeared unconscious and bled heavily from one ear, "tripped and fell".
Local media later reported the man was in stable condition and an internal investigation of the officers involved had been launched.
In Richmond, protesters gathered around a statue of Robert E Lee, after Virginia governor Ralph Northam announced plans to remove the Confederate leader monument.
A Republican senator, Lisa Murkowski of Alaska, broke ranks with her party meanwhile and revealed she was "struggling" with whether to support President Donald Trump's re-election.
Ms Murkowski said her move was prompted by remarks from Mr Trump's former defence secretary James Mattis, who a day earlier delivered a biting assessment of a president who "tries to divide us".
"I thought General Mattis's words were true and honest and necessary and overdue", Ms Murkowski told reporters.
Her comments mark a major break with Mr Trump within the Republican camp, which has largely held together through various crises including his impeachment and current threat to use military force against protests.
'Frankly criminal'
While condemning Mr Floyd's death, Mr Trump has adopted a tough stance towards the protesters, saying they include many "bad people" and calling on governors to "dominate the streets".
US civil rights groups filed a case yesterday suing Mr Trump, after security forces fired pepper balls and smoke bombs to clear peaceful demonstrators outside the White House before the president walked to a church for a photo op earlier this week.
Low-flying helicopters were also used in an apparent show of force above protesters in Washington, DC on Monday night.
Mr Trump tweeted: "The problem is not the very talented, low-flying helicopter pilots wanting to save our city, the problem is the arsonists, looters, criminals, and anarchists, wanting to destroy it (and our Country)!"
'All-inclusive'
Democratic Congressman John Lewis, who marched with Martin Luther King Jr to fight segregation, echoed Mr Sharpton's hope that Mr Floyd's death could pave the way for "greater change".
The 80-year-old civil rights icon told "CBS This Morning" that the current protests felt "so much more massive and all-inclusive".
He also condemned Mr Trump's threat to use military force against demonstrators.
Some of the protests were marred by rioting and looting in the early days, but they have been mostly peaceful since then.
Three of the four Minneapolis police officers who arrested Mr Floyd for allegedly passing a counterfeit bill made their first court appearance to face charges of aiding and abetting his murder.
Bail was set at $1m each.
The fourth policeman, Derek Chauvin, has been charged with second-degree murder and appeared before a judge last week.
