The BBC is to cut 450 jobs in its news division as part of a cost-cutting and modernisation drive.
Plans to axe Victoria Derbyshire's BBC Two programme have already been leaked, with the host saying she is "absolutely devastated".
There will also be a a reduction in the number of films produced by Newsnight, which will lead to job losses.
There will also be job cuts at 5Live as well as a review of the number of presenters the BBC has and how they work.
In addition, World Update on World Service English will be closed.
BBC News has to save £80m as part of financial pressures on the corporation, including paying for free TV licences for over-75s on pension credit.
It is expected that BBC Radio bulletins across different stations will share more resources.
The cuts also come amid payouts to some female staff, with radio presenter Sarah Montague getting a £400,000 settlement and Samira Ahmed winning an employment tribunal in a dispute over equal pay.
They are being announced as the corporation starts the search for a new director-general with Tony Hall announcing he will step down from the role in the summer.
In comments from a media event published in the Daily Telegraph, Lord Hall said the BBC has contributed to a toxic discourse through political journalism aimed at trying to "catch out" politicians, adding he was "great believer in the long-form interview where you can explore at length".
BBC Director of News and Current Affairs Fran Unsworth told staff the move to end Ms Derbyshire's daily BBC Two current affairs programme had "not been an easy decision".
Ms Derbyshire, 51, said she first found out about the plans in a newspaper.
She said her Bafta-winning show had delivered on its remit, breaking original stories and "attracting a working class, young, diverse audience".
Confirming the decision, Ms Unsworth said: "Linear television viewing is declining, and as we progress with our £80m savings target, it is no longer cost-effective to continue producing the programme on television."
A petition to save the programme has reached more than 30,000 signatures.