Israeli troops have shot and killed one Palestinian and injured 120 during a large protest on the Gaza-Israel border in which demonstrators hurled stones and burned tyres near the frontier fence, the Palestinian health ministry said.
The Israeli military said some in the Gaza crowd threw firebombs and an explosive device.
Thousands of Palestinians arrived at tented camps near the frontier as a protest dubbed The Great March of Return - evoking a longtime call for refugees to regain ancestral homes in what is now Israel - moved into its third week.
Israeli troops have shot dead 30 Palestinians and wounded hundreds since the protests began, drawing international criticism.
An Israeli military spokesman said troops were confronted by rioters and "responding with riot dispersal means while also firing in accordance with the rules of engagement."
Groups of youths waved Palestinian flags and burnt hundreds of tyres and Israeli flags near the fenced-off border after Friday prayers.
At one camp east of Gaza City, youths carried on their shoulders a coffin wrapped in an Israeli flag bearing the words "The End of Israel."
Israel has declared a no-go zone close to the Gaza border fence, and deployed army sharpshooters along it.
No Israelis have been killed during the demonstrations, and human rights groups say the Israeli military has used live fire against demonstrators who pose no immediate threat to life.
Israel says it is doing what it must to defend its border, and to stop any of the protesters getting across the fence.
The planned six-week protest has revived a longstanding demand for the right of return of Palestinian refugees to towns and villages from which their families fled, or were driven out, when the state of Israel was created 70 years ago.
The protest began on 30 March, and is expected to culminate on 15 May.
That is the day Palestinians will mark the 70th anniversary of the "Nakba" or "Catastrophe", when hundreds of thousands of Palestinians were displaced amid violence culminating in war between newly created Israel and its Arab neighbors in May 1948.
Successive Israeli governments have ruled out any right of return, fearing the country would lose its Jewish majority.
The Israeli government accuses Hamas, the Islamist movement that has ruled Gaza largely since Israeli soldiers and settlers withdrew in 2005, of having instigated the protests and of using them as cover to launch attacks.
