At least four people were killed and 11 injured after a UPS wide-body cargo plane crashed in Louisville, Kentucky, erupting into a massive fireball shortly after take-off, Kentucky Governor Andy Beshear said at a press briefing.
"We believe we have at least four fatalities. I believe that number is going to get larger," Mr Beshear said.
The plane took off with fire on one wing, and a huge fireball erupted as it hit the ground.
"UPS Flight 2976 crashed around 5.15pm local time, after departing from Louisville Muhammad Ali International Airport in Kentucky," the Federal Aviation Administration said in a statement. The plane was en route to Honolulu, it said.
Several buildings in an industrial area beyond the runway were on fire after the crash, with thick black smoke rising into the evening sky.
Louisville Metro Emergency Services said it had issued a shelter-in-place order for all locations within 8km of the airport.
"There are multiple injuries and the fire is still burning. There are many road closures in the area - please avoid the scene," Louisville Mayor Craig Greenberg said in a social media post shortly before 7pm local time (12am Irish time).
Crash involved 34-year-old plane
FAA records show the plane involved in the crash, an MD-11 freighter, was 34 years old.
Boeing, which shut down the MD-11 programme after acquiring it in its merger with McDonnell Douglas, said it was concerned for the safety and well-being of those affected, and it would provide technical support to the investigation.
Flightradar24 said the plane, which began operations with UPS in 2006, had flown from Louisville to Baltimore earlier yesterday before returning to Louisville.
The flight from Louisville to Honolulu typically takes eight and a half hours, the flight tracking service said.
The aircraft climbed to an altitude of 175 feet and reached a speed of 184 knots before making a sharp descent, according to data from Flightradar24.
A National Transportation Safety Board spokesperson said it would be leading the investigation and it was sending a team to the site.
The NTSB typically takes 12 to 24 months to complete an investigation, make a finding of probable cause and issue recommendations to help avoid similar incidents.
The Louisville airport is home to UPS Worldport, a global hub for the delivery firm's air cargo operations and its largest package handling facility in the world.
The Louisville airport said the airfield was closed after the incident. The crash will likely disrupt deliveries for UPS, and its major customers including Amazon, Walmart and the United States Postal Service.
Walmart and Amazon did not immediately respond to requests for comment.
