New York prosecutors will begin closing arguments in their case against former movie producer Harvey Weinstein who is accused of rape and sexual assault, a day after his lawyers accused the prosecution of being "over zealous."

Assistant District Attorney Joan Illuzzi is expected to deliver the closing argument for the Manhattan District Attorney's office, setting the stage for the jury to begin deliberating next week.

Mr Weinstein, 67, has pleaded not guilty to sexually assaulting former production assistant Mimi Haleyi in 2006 and raping Jessica Mann, a one time aspiring actress, in 2013.

The trial is a milestone for the #MeToo movement in which women have accused powerful men in business, entertainment, media, and politics of sexual misconduct.

Since 2017, more than 80 women have accused Mr Weinstein of sexual misconduct.

The former producer, who was behind films including 'The English Patient' and 'Shakespeare in Love', has denied any non-consensual sex.

Yesterday, Donna Rotunno, one of  his lawyers, described his accusers as unreliable and said an "overzealous" prosecution was trying to portray consensual sex as assault.

"They are creating a universe in which they are stripping adult women of common sense, autonomy and responsibility," she said during a nearly five-hour closing argument.

Ms Haleyi testified during the trial that Mr Weinstein sexually assaulted her at his home in 2006.

Ms Mann testified that Mr Weinstein raped her in a Manhattan hotel room early in what she called an "extremely degrading" relationship with him.

Jurors heard from four other women, including actress Annabella Sciorra, who testified that Mr Weinstein came into her apartment one winter night in 1993 or 1994 and raped her.

The allegation is too old to be charged as a separate crime, but it could act as an aggravating factor to support the most serious charge in the case, predatory sexual assault, which carries a possible life sentence.

The prosecutors called the remaining three women to bolster their evidence of Mr Weinstein's intent, but did not charge him with any crimes related to them.

Justice James Burke is expected to give the jury legal instructions on Tuesday morning, after which they will begin deliberating.