Democrat Joe Biden has won the White House, defeating Donald Trump and ending a presidency that convulsed American politics, shocked the world and left the United States more divided than at any time in decades.
CNN, NBC News and CBS News called the race in Mr Biden's favour just before 4.30pm as an insurmountable lead in Pennsylvania took the 77-year-old over the top in the state-by-state count that decides the presidency.
In a statement, Donald Trump disputed the call and said the election was far from over.
Earlier, as he headed to his golf course in Virginia, he tweeted "I WON THIS ELECTION, BY A LOT!"
However, the result now condemns 74-year-old Trump to becoming the first one-term president since George HW Bush at the start of the 1990s.
Mr Biden, who got the votes of a record more than 74 million people, was hunkered down with his running mate Kamala Harris, in his home town of Wilmington, Delaware.
Late Friday he delivered an address urging Americans to "come together as a nation and heal".
The Secret Service has already begun intensifying its protective bubble around the president-elect, who will be inaugurated on 20 January.
A centrist who promises to bring calm to Washington after four turbulent years under Mr Trump, Mr Biden is the oldest man to win the presidency, a position he twice sought unsuccessfully during his long political career, before being elected vice president to Barack Obama in 2008.
Ms Harris, a senator and former California attorney general, will make history as the first Black woman to enter the White House in either of the two top jobs.
At 56, she is seen as a leading contender to succeed Biden and try to become the first female US president.
Overall turnout on Tuesday broke records with 160 million people pouring out across the United States after a deeply polarising campaign complicated by the resurgent Covid-19 pandemic.
Mr Biden secured his win by recapturing the Midwestern states of Pennsylvania, Michigan and Wisconsin -- traditional Democratic territory that Trump had flipped in 2016 with his powerful appeal to white, working class voters.
With Pennsylvania in the bag, Mr Biden has now accumulated 273 out of 538 Electoral College votes, clearing the bar of 270, thereby making it impossible for Mr Trump to get a second term even if he were to win the remaining undeclared states.
Edison Research has also called Nevada for Mr Biden.
Mr Biden was also ahead in Arizona, and in a near dead heat in Georgia, a southern state that has not voted for a Democratic presidential candidate since Bill Clinton in 1992 and is now headed for a recount.
Results from congressional races indicate that Mr Biden will face a divided legislature, with his Democrats holding a majority in the House and Republicans clinging to control of the Senate -- although that could still shift.
The division in Washington will likely complicate immediately Biden's ability to govern, starting with disputes in Congress over a delayed economic stimulus package for Americans hammered by the fallout from the coronavirus crisis.