Figures released by Children's Health Ireland to Aontú leader Peadar Tóibín show that 126 incidents that resulted in long-term disability, permanent incapacity or death were reported by CHI over a five-year period.
Mr Tóibín said the figures are harrowing.
"We are talking about 126 individuals who have been victims of major or extreme incidents," he said.
"These are not just statistics; these are children and families who have suffered long-term disability or life-altering incapacity. In some cases, we are looking at possible deaths."
The information supplied to Mr Tóibín shows CHI reported over 31,000 incidents within the five-year period, including the 126 "major or extreme" incidents.
All were reported by CHI to the HSE’s National Incident Management System between January 2020 and July 2025. They were divided into four categories based on their severity of harm and level of risk.
There were 752 "moderate" incidents which resulted in injuries that required professional medical treatment, and 23,283 minor or negligible incidents.
A further 6,930 "other" incidents related to dangerous occurrences linked to systemic or ICT failures and "inadequate" or "environmental" factors.
The CHI said the incidents spanned a range of clinical and non-clinical categories, including clinical care-related events, staff and service user safety incidents, workplace hazards and complaints or service user experience.