Minister of State Neale Richmond has said that nine or ten ministers will visit up to 15 US states around St Patrick's Day.
Taoiseach Micheál Martin has also insisted that he will visit the White House in March despite calls from some Opposition parties that he should boycott the traditional visit.
Mr Richmond told the Dáil that the ministers would seek to build and maintain political and economic links in the US.
"If you're not at the table, you're on the menu," he said.
The full list of locations across the globe that will be visited by ministers could be revealed as soon as Tuesday next.
Senior Government figures indicated this evening that this year's message from Ireland will focus on its stability as a place to do business as well as being a gateway to EU markets.
Ministers will point out that Ireland is "a small country that has made a big impact".
Minister of State Michael Healy-Rae, who stayed home last year when his ministerial colleagues made overseas visits, confirmed that he will be dispatched abroad in March.
He described himself as a "reluctant traveller" who does not like leaving the country.
