Tánaiste Simon Harris will travel to Brussels for a meeting of EU finance ministers, which is set to be dominated by concerns over US President Donald Trump's latest tariff threats.
Over the weekend, Mr Trump threatened to introduce a 10% tariff by the start of February on eight European nations that have sent troops to Greenland.
He also vowed to increase this rate to 25% by the start of June unless a deal on Greenland is struck.
The eight countries are EU member states Denmark, Sweden, Finland, Netherlands, France and Germany, as well as non-EU member states Norway and the United Kingdom.
While a meeting of EU ambassadors yesterday evening downplayed suggestions from French President Emmanuel Macron that an "anti-coercion instrument" of financial measures could be used in retaliation to the threats, a number of actions remain open.
These include the instigation of €93 billion worth of retaliatory tariffs that were put on hold after last summer's EU-US tariffs deal, MEPs not signing off on the implementation of that deal this week in Strasbourg, or a later introduction of the anti-coercion instrument financial measures.
The situation is certain to dominate much of this week, with Mr Trump and a number of EU leaders due to attend the World Economic Forum meeting in Davos in Switzerland on Wednesday.
European Council President António Costa has already called an emergency meeting of European leaders on Thursday.
The matter will be the key focus of today's ECOFIN meeting of EU finance ministers in Brussels.
Speaking ahead of the meeting, the Tánaiste and Minister for Finance said EU officials worked to strike a tariffs deal with the US last year to ensure "certainty and clarity" for the economy.
He added that the latest threats are "a clear breach of that agreement".
Mr Harris said any new tariffs would be damaging to the EU economy, supply chains and open trade, adding such levies must be avoided.
He said: "I intend to raise with my European counterparts the latest economic developments with the US, including those linked to Greenland.
"At a time of heightened global uncertainty, it is vital that we avoid actions that risk further instability.
"The focus must be on working together to protect all of our economies across the EU."
In a statement last night, Minister for Foreign Affairs Helen McEntee said Mr Trump's latest tariff threats and the ongoing US push to take over Greenland must be opposed.
She said Ireland "reiterated its solidarity with Denmark and the people of Greenland, as well as with the six EU member states that may now face increased tariffs from the United States" during the meeting of EU ambassadors.
"These tariffs are not compatible with the EU-US agreement and they risk undermining the strength of our trans-Atlantic relationship at a time when co-operation matters more than ever," Ms McEntee said.
"I will continue to work closely with our EU partners on the appropriate next steps," she added.
This, she said, "will be a priority in the days ahead".
Ms Entee welcomed Mr Costa's announcement that he will convene "an extraordinary meeting of the European Council to address these developments".
