Taoiseach Micheál Martin has pledged €21.6 million in Irish funding to Gavi, the world vaccine alliance group.
The announcement came at a global summit which aims to raise at least $9 billion (€7.8bn) to support Gavi's work.
The alliance provides access to vaccines to immunise the world’s poorest children.
Between 2026-2030, Gavi aims to immunise a further 500 million children, save over eight million lives and protect against up to 150 disease outbreaks.
Mr Martin said the extra funding represents a 20% increase in Irish support for the alliance.
"Vaccines have utterly transformed health outcomes across the world. Evidence from the World Health Organisation shows that vaccination is one of the best health investments that money can buy and one of the most impactful tools that we have available to us," he said.
Ahead of today’s summit, the Taoiseach met Chair of the Gates Foundation Bill Gates where the issues of gender equality, agriculture, nutrition and global health were discussed.
Meanwhile, Tánaiste and Minister for Foreign Affairs Simon Harris said that Ireland was proud to increase its support to the work of Gavi.
"This support from Ireland will help keep people safe and healthy, protecting them from diseases and illnesses that continue to cost too many lives," he added.
