Taoiseach Micheál Martin and Tánaiste Simon Harris are among 38 State representatives who will visit more than 90 cities in 40 countries for St Patrick's Day celebrations.
The Cabinet has signed off on the plan, brought to the meeting by Mr Harris.
Mr Martin, Mr Harris and a number of other ministers will travel to the United States during the week of St Patrick's Day.
They will speak about the mutually beneficial economic relationship between Ireland and the US, valued at over €1 trillion per annum.
As things stand, there has been no confirmation from the White House of the Taoiseach's traditional visit.
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However, Government figures insist this is not irregular as the engagement is typically finalised close to 17 March.
Mr Martin is scheduled to visit Washington and Texas while Mr Harris will travel to New York and Philadelphia.
During the trips, the Government will emphasise that Ireland is a small, open economy with its economic success rooted in its willingness to build partnerships.
Ministers will highlight Irish investment overseas and the success of companies that have chosen Ireland as their base in Europe.
Speaking on his way into Cabinet, Mr Martin said that he fully expects to meet US President Donald Trump.
He said it is important the visits are maintained "no matter who is the US President".
"There is never actually a specific invitation. It just gets worked out between the two administrations. We're anticipating the tradition will be continued again."
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Mr Martin said the visits by ministers are "important, given our global trading position, and also to meet with the Irish diaspora and Irish communities across the globe who celebrate St Patrick's Day".
"There's a particular focus on the United States this year, and given our extended diplomatic footprint that we've established over the last number of years in different states."
Tánaiste Simon Harris said comments that the Taoiseach should not meet the US President "go against Ireland's national interest".
Yesterday, Solidarity-People Before Profit TD Ruth Coppinger said Mr Martin should "not go to the White House on St Patrick's Day" due to President Trump's policies.
Mr Harris said: "I've heard some commentary anyway, that perhaps it shouldn't [go ahead]. I think that would be entirely against our national interest.
"It's really important that he should, whoever he or she is, engages with the president of the day, whoever he or she is, and it's a really important asset for that country and for strengthening bilateral relations."
We need your consent to load this rte-player contentWe use rte-player to manage extra content that can set cookies on your device and collect data about your activity. Please review their details and accept them to load the content.Manage PreferencesYesterday, the SDLP ruled out attending any events for St Patrick's Day in Washington next month.
Ministers travelling to the United States:
- Taoiseach Micheál Martin - Texas and Washington DC
- Tánaiste Simon Harris - Philadelphia and New York
- Darragh O'Brien - Miami and Los Angeles
- Peter Burke - Boston and New Hampshire
- Dara Calleary - Atlanta and Savannah
- Patrick O'Donovan - Seattle and San Francisco
- Jennifer Carroll MacNeill - UN Commission on the Status of Women, New York and Chicago
- Attorney General - Rossa Fanning Michigan and Montana
- Alan Dillon - Utah (and Vancouver in Canada)
Ministers travelling to other locations:
- Paschal Donohoe - Germany
- Jack Chambers - Chile and Argentina
- Norma Foley - London
- Helen McEntee - Australia
- Jim O'Callaghan - Italy, Holy See and Malta
- James Browne - China
- James Lawless - India
- Mary Butler - Denmark and Sweden
- Hildegarde Naughton - Japan
- Noel Grealish - Vietnam and Cambodia
- Sean Canney - Brazil
- Thomas Byrne - France
- Charlie McConalogue - Colombia
- Kevin Boxer Moran - Portugal
- Emer Higgins - Western Australia
- Robert Troy - Czech Republic
- Neale Richmond - Kenya and Tanzania
- Jerry Buttimer - New Zealand
- John Cummins - Thailand and the Philippines
- Christopher O'Sullivan - Norway and Poland
- Kieran O'Donnell - Cardiff and Manchester
- Jennifer Murnane O'Connor - Greece and Cyprus
- Niall Collins - Mexico
- Niamh Smyth - Finland, Estonia, Latvia and Lithuania
- Timmy Dooley - Canada
- Colm Brophy - Spain
- Marian Harkin - Netherlands & Belgium
Other visits:
- Ceann Comhairle Verona Murphy - Switzerland
- Cathaoirleach Seanad Mark Daly - Edinburgh
Additional reporting Carla O'Brien
