The Cabinet has approved the appointment of junior ministers following a reshuffle of some positions.
Two Fine Gael TDs, Jennifer Carroll MacNeill and Kieran O'Donnell, have been promoted from the backbenches.
The big move of the day was the appointment of Peter Burke to the role of European Affairs Minister.
Community Development Minister Joe O'Brien will now also assist the Department of Integration in overseeing the accommodation of those seeking refuge in Ireland.
Hildegarde Naughton, already appointed to the Department of the Taoiseach as Government Chief Whip, has been assigned additional responsibilities to also be a Minister of State at the Department of Health.
The Government has already appointed Jack Chambers as Minister for International and Road Transport and Logistics at the Department of Transport, as well as Minister for Postal Policy at the Department of the Environment, Climate and Communications.
Senator Pippa Hackett was also appointed as Minister for Land Use and BioDiversity at the Department of Agriculture.
This reshuffle of junior ministers has proved to be more substantial than Saturday's rotation of the senior ranks.
Drugs Strategy Minister Frank Feighan and Overseas Aid Minister Colm Brophy have both left office.
Sean Fleming has been appointed Minister of State at the Department of Foreign Affairs to oversee International Development and the Diaspora.
Thomas Byrne becomes Minister for Sport, and Niall Collins retains his position in Higher Education.
Speaking this evening, Taoiseach Leo Varadkar said: "Having emerged from Covid, we face major challenges in the years ahead.
"We must treat each challenge as a national emergency and deploy the full resources of the State, the full machinery of Government, to make an immediate and real difference.
"These Ministers of State will play a vital role in that response, and in delivering the remainder of the Programme for Government."
Kerry Fine Gael TD Brendan Griffin today thanked Mr Varadkar for considering him for a role, but said he was unable to accept due to family reasons.
In a statement to RTÉ News, Mr Griffin said: "I wish my friend and colleague, An Taoiseach Leo Varadkar, every success in his important work for our country and I thank him for considering me.
"I send my heartiest congratulations to my colleagues who have been appointed to ministerial roles and wish them well in their difficult work. They will all have my full support in their endeavours."
Today's Cabinet deliberations on this issue will take place with all mobile devices left outside the room after Mr Varadkar asked ministers to follow this rule for security reasons.
Full list of junior ministers
Peter Burke - Department of the Taoiseach and the Department of Foreign Affairs (EU Affairs) and the Department of Defence
Patrick O'Donovan - Department of Public Expenditure and Reform (OPW) and Department of Tourism, Culture, Arts, Gaeltacht, Sport and Media (Gaeltacht)
Ossian Smyth - Department of Public Expenditure and Reform (Public Procurement and eGovernment) and Department of the Environment, Climate and Communications (Communications and Circular Economy)
Josepha Madigan - Department of Education (Special Education and Inclusion)
Martin Heydon - Department of Agriculture, Food and the Marine (Research and Development, Farm Safety and New Market Development)
Anne Rabbitte - Department of Health and the Department of Children, Equality, Disability, Integration and Youth (Disability)
Sean Fleming - Department of Foreign Affairs (International Development and Diaspora)
Joe O'Brien - Department of Rural and Community Development and Department of Social Protection (Community Development and Charities) and Department of Children, Equality, Disability, Integration and Youth (Integration)
Kieran O'Donnell - Department of Housing, Local Government and Heritage (Local Government and Planning)
Malcolm Noonan - Department of Housing, Local Government and Heritage (Heritage and Electoral Reform)
Damien English - Department of Enterprise, Trade and Employment (Employment Affairs and Retail Business) and Department of Social Protection
Mary Butler - Department of Health (Mental Health and Older People)
Thomas Byrne - Department of Tourism, Culture, Arts, Gaeltacht, Sport and Media (Sport and Physical Education)
Niall Collins - Department of Further and Higher Education, Research Innovation and Science (Skills and Further Education)
Jennifer Carroll MacNeill - Department of Finance (Financial Services, Credit Unions and Insurance)
James Browne - Department of Justice (Law Reform and Youth Justice)
Dara Calleary - Department of Enterprise, Trade and Employment (Trade Promotion and Digital Transformation)
Hildegarde Naughton - Already appointed Government Chief Whip, has been assigned additional responsibilities to also be a Minister of State at the Department of Health (Public Health, Well Being and the National Drugs Strategy).
Jack Chambers - Minister for International & Road Transport & Logistics at the Department of Transport, as well as Minister for Postal Policy at the Department of the Environment, Climate and Communications.
Senator Pippa Hackett - Minister for Land Use and BioDiversity at the Department of Agriculture.
