Independent Senator Sharon Keogan has resigned from the Joint Oireachtas Committee on Children, Equality, Disability, Integration and Youth.
In an email to Committee Chair Kathleen Funchion and fellow members, with the subject line "Unsafe Working Environment/ Resignation", she said that she no longer feels safe or protected as a member of the committee.
Ms Keogan said that she will continue to sit on the Joint Committee on International Surrogacy.
Last week, the Committee on International Surrogacy was suspended after Senator Keogan was accused of being "crude and cold" towards those who had shared their experiences.
Ms Funchion chaired last week's meeting as the committee's chair Jennifer Whitmore was unable to attend.
It is understood that Ms Keogan was unhappy with how the meeting was handled.
She said that she would offer her place on the children's committee to an Independent Senator from her grouping.
The Chair of the Oireachtas Children's Committee has said that she was "surprised" to learn of Senator Keogan's decision to resign.
In a statement, Ms Funchion said: "It is always disappointing when any member resigns from a committee and I thank her for her contribution."
She also said that she would like to "clarify that any allegations or issues that were referenced in her letter were not brought to the attention of the children's committee prior to receipt of her letter today".