Minister for Finance Paschal Donohoe is on a four-day visit to Washington DC and New York, with the focus on tax and Brexit.
Mr Donohoe will give a keynote address on the impact of Brexit on Ireland to the Washington-based think-tank, the Brookings Institution.
He will discuss what is described as "a wide range of issues including Ireland's strong bilateral economic relationship, EU-US relations, as well as international tax issues".
It is understood Mr Donohoe will be keen to discuss US tax changes as US President Donald Trump and congressional Republicans are determined to reform the tax code before the end of the year.
He will be stressing that Ireland's tax code meets international standards given the recent commentary in the US equating Ireland to an international tax haven.
Mr Donohoe said: "The key objective of my visit to Washington DC is to engage with the US Administration and with both sides of Congress on issues such as international trade, the importance of a global approach to tax and the challenge of Brexit.
"I will be updating a number of our key political contacts on developments in Ireland, including our continued economic progress and the ongoing work to prepare for Brexit.
"While here I will also be emphasising the continued importance of the Ireland-US economic trade relationship."
Mr Donohoe will also meet officials from the International Monetary Fund and World Bank.