Israeli emergency services say three people were killed and 74 wounded following Iran's latest missile strikes.
It said two women and one man had been killed, without giving a precise location, but adding rescue operations were ongoing in two places.
Israel and Iran have launched fresh attacks, killing and wounding civilians and raising concerns of a broader regional conflict, with both militaries urging civilians on the opposing side to take precautions against further strikes.
German Chancellor Friedrich Merz said he hoped a meeting of the Group of Seven leaders convening in Canada would reach an agreement to help resolve the conflict and keep it from escalating.
The Israeli military, which launched the attacks on Friday with the stated aim of wiping out Iran's nuclear and ballistic missile programs, warned Iranians living near weapons facilities to evacuate.
"Iran will pay a heavy price for the murder of civilians, women and children," Israeli Prime Minister Benjamin Netanyahu said from a balcony overlooking blown-out apartments where six people were killed in Bat Yam, a town south of Tel Aviv.
Iran's armed forces told residents of Israel to leave the vicinity of "vital areas" for their safety.
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"Do not stay or travel near these critical areas," an Iranian armed forces spokesperson said in a video broadcast by state TV around the time that Iran sent a new barrage of missiles towards Israel.
Death toll rises
In Israel, rescue teams combed through rubble of residential buildings destroyed by Iranian missiles, using sniffer dogs and heavy excavators to look for survivors after at least 10 people, including children, were killed, raising the two-day toll to 13.
Explosions rattled Tel Aviv in the afternoon as Iran launched its first daylight missile raid since Israel attacked on Friday.
There were no immediate reports of direct hits in the initial barrage.
Hours later, shortly after nightfall, Iran launched a second wave of missiles, which struck Haifa, a mixed Jewish-Arab city in northern Israel.
An Israeli military official said that an elderly care facility was hit.
The national emergency service reported nine people were injured in the strike, along with two others following a missile impact in southern Israel.
In Iran, images from the capital showed the night sky lit up by a huge blaze at a fuel depot after Israel began strikes against Iran's oil and gas sector - raising the stakes for the global economy and the functioning of the Iranian state.
Iran has not given a full death toll but said 78 people were killed on Friday and scores more have died since, including in a single attack that killed 60 on Saturday, half of them children, in a 14-storey apartment block flattened in Tehran.
Trump vetoes plan to target Khamenei, officials say
In Washington, two US officials told Reuters that US President Donald Trump had vetoed an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei.
"Have the Iranians killed an American yet? No. Until they do we're not even talking about going after the political leadership," said one of the sources, a senior US administration official.
When asked about the Reuters report, Israeli Prime Minister Benjamin Netanyahu told Fox News: "There's so many false reports of conversations that never happened, and I'm not going to get into that."
"We do what we need to do," he said.
Regime change in Iran could be a result of Israel's military attacks, Mr Netanyahu said in the interview, adding that Israel would do what it takes to remove what he called the "existential threat" posed by Tehran.
Israel's military spokesperson has said the current goal of the campaign is not regime change, but the dismantling of Iran's nuclear and ballistic missile programs and removing its capabilities "to annihilate us".
Israel launched a surprise attack on Friday morning that wiped out the top echelon of Iran's military command and damaged its nuclear sites, and says the campaign will escalate in coming days.
The intelligence chief of Iran's Revolutionary Guards, Mohammad Kazemi, and his deputy were killed in Israeli attacks on Tehran, Iran's semi-official Tasnim news agency said.
