The Israeli army said it attacked a southern Beirut building which it claimed was being used to store precision missiles belonging to Hezbollah.
The attack was a further test of a fragile ceasefire between Israel and Hezbollah.
A huge plume of smoke billowed from the building, Reuters live footage showed, almost an hour after the Israeli army issued an evacuation order to residents of the Hadath neighbourhood.
Israeli Defence Minister Israel Katz claimed in a statement that Hezbollah's precision missiles "posed a significant threat to the State of Israel".
There was no immediate comment from Hezbollah.
This latest Israeli attack adds to strains on the US-brokered ceasefire that ended last year's conflict between Israel and Hezbollah.
"Today's strike on the southern suburbs of Beirut generated panic and fear of renewed violence among those desperate for a return to normalcy," Jeanine Hennis-Plasschaert, UN Special Coordinator for Lebanon, said on X, formerly Twitter.
"We urge all sides to halt any actions that could further undermine the cessation of hostilities understanding and the implementation of SCR 1701," she added, referring to the UN Security Council resolution that ended the month-long war between Israel and Hezbollah in 2006.
Lebanese President Joseph Aoun called on the US and France, as guarantors of the ceasefire agreement struck in November, to compel Israel to stop its attacks.
"Israel's continued actions in undermining stability will exacerbate tensions and place the region at real risk, threatening its security and stability," he said in a statement.
Earlier this month an Israeli airstrike killed four people, including a Hezbollah official, in Beirut's southern suburbs -the second Israeli strike on the Lebanese capital in five days.
The attacks on southern Beirut have resumed at a time of broader escalation in hostilities in the region, with Israel having resumed its attacks on Gaza breaking a two-month truce and the US attacking the Houthis of Yemen in a bid to get them to stop attacking Red Sea shipping.
Israel has dealt severe blows to Hezbollah in the war, killing thousands of its fighters, destroying much of its arsenal and eliminating its top leadership, including Hassan Nasrallah.
Hezbollah has denied any role in recent rocket attacks from Lebanon towards Israel.
Meanwhile, the IDF also claimed it has killed a Hezbollah militant in a strike in southern Lebanon's Halta area.
"Earlier today, the IDF (military) struck in the area of Halta in southern Lebanon and eliminated a Hezbollah terrorist who advanced Hezbollah's attempts to re-establish itself in the Halta area," the military said.
Israel says intercepts missile fired by Yemen's Houthis
The Israeli military said it intercepted a missile fired from Yemen, where the Houthis claimed responsibility for the launch, saying it targeted an air base in southern Israel.
"The missile that was launched from Yemen was intercepted...prior to crossing into Israeli territory," a military statement said.
Yemen's Houthis said they had launched a "hypersonic missile" at the Nevatim air base in Israel's Negev desert.
The Israeli military said it intercepted a drone that "approached the Israeli territory from the east".
It did not specify from where the drone was launched.
The Houthis, part of Iran's "axis of resistance" against Israel and the United States, have said their attacks are in solidarity with Palestinians in Gaza amid Israel's ongoing war.
They have launched repeated missile and drone attacks on both Israel and merchant shipping in the Red Sea and the Gulf of Aden, prompting retaliatory air strikes by Israel, Britain and the United States.
Since President Donald Trump took office in January, the US air campaign has intensified, with almost daily strikes for the past month.
According to Israel's army radio, the Houthis have fired more than 20 missiles at Israel since they resumed their attacks when Israel renewed its attacks on Gaza on 18 March ending a two-month ceasefire
