The Government has announced an allocation of €20 million to support the work of UNRWA, the United Nations' Palestinian Relief Agency.
Tánaiste and Minister for Foreign Affairs Simon Harris said the funding is to assist the organisation's work in providing assistance to people in Gaza, the West Bank and Palestine refugees across the Middle East.
Mr Harris described the humanitarian situation in Gaza as catastrophic.
An Israeli order banning UNRWA from operating in the country came into force at the end of last month.
It also prohibits contact between the agency and Israeli officials after Israel accused the agency of providing cover for Hamas militants.
The UN responded by saying the organisation would continue working in all Palestinian territories, including east Jerusalem.
In a statement, Mr Harris said the funding "announcement underscores Ireland’s commitment to ensuring that there is a significant and meaningful surge in humanitarian aid into Gaza at this critical time.
"There is no replacement for the work of UNRWA and it is vital that it is supported.
"UNRWA delivered more than 60% of the supplies that entered Gaza in the first days of the ceasefire.
"It is the only organisation with the scale to deliver and support the restoration of health, social services, and education for more than 300,000 children in Gaza," he added.
Ireland has provided over €63m in support of the Palestinian people since the beginning of 2023.
