Primary teachers' union the INTO has said it fully supports a statement issued by global federation of teacher unions Education International which condemns the recent military strikes on Iran.
The Education International statement included references to reported attacks on two schools on 28 February - Shajare Tayyiba elementary school for girls in Minab and a high school in Tehran.
The Irish National Teachers' Organisation said it offered its solidarity with the school communities impacted.
The INTO said it agreed unequivocally with Education International's description of the killing and wounding of students and teachers as "an intolerable violation of human rights and a grave breach of international humanitarian law".
The Irish trade union said schools must never be targets.
"The reported loss of life among children and teachers is devastating and wholly unacceptable" it said in a statement.
"Children and teachers are not combatants, and the targeting of civilian infrastructure, including schools, can never be justified," it added.
INTO General Secretary John Boyle said the deliberate targeting of schools "strikes at the very heart of humanity".
He said schools must be protected as safe spaces for children and teachers at all times.
"We stand with our global education union colleagues in demanding an immediate end to attacks on civilians and a renewed commitment to peace, international law, the principles of the Safe Schools Declaration and the protection of education throughout the region," Mr Boyle said.
The INTO said it remained concerned for the safety of members and Irish teachers across the Middle East.
It urged anyone based in the region to register with the Department of Foreign Affairs and Trade and follow their advice.
