Taoiseach Simon Harris has described the shooting of Donald Trump as a heinous act of political violence and said politicians must "dial down the rhetoric" when it comes to demonising opponents.
Speaking in Dublin, Mr Harris said that the shooting was "shocking".
"I'm relieved that former president Trump is secure and well, but we must always call out political violence," Mr Harris said.
He also said that his thoughts are with the person who died in the incident, as well as those who were injured.
"My thoughts today are with the person who lost their life - the innocent spectator who went to a political event and found themselves caught up in this - and indeed those who are critically injured and I'm pleased that [former] president Trump is well and we send him our best."
Earlier, speaking on the Sunday Politics Show on BBC Northern Ireland, the Fine Gael leader said he was relieved that the former US president is secure and well.
"Political violence must always be condemned and always be called out, and I must say it is quite alarming the rise that we're seeing in political violence across the world. It's only weeks since my Slovakian counterpart [Robert Fico] had an attempt on his life as well," he said.
The Taoiseach said the fact that two fierce political rivals President Biden and Mr Trump spoke by telephone after the attack was a "glimmer of hope"
"It's so important that political violence is condemned and, and of course I want to send former President Trump our very best wishes and his family and all of those caught up in this horrific heinous political act last night," he added.
Follow live updates in the aftermath of the shooting of Donald Trump
Asked about increasing toxicity in political debate, he said: "I do think the situation around political toxicity is something that absolutely needs real leadership now, real leadership in the United States, real leadership in Europe, real leadership here on this island as well, and we must dial down the rhetoric when it comes to demonising political opponents.
"It is so important and that we work out a way of engaging and robustly debating issues without dehumanising people.
"Of course, I don't know enough about the background or circumstances of last night, but what I absolutely do know is that political violence has no place and that what happened last night is absolutely, absolutely unacceptable and must be condemned by all of us.
"Certainly condemned by me. "
Shooting 'gives us all pause for concern'
The Sinn Féin leader has described the assassination attempt on former US President Donald Trump as "deeply, deeply shocking."
Mary Lou McDonald said her first thoughts are with the man who lost his life and with his family and the other people who were injured in the gun attack.
Speaking to RTÉ News, Ms McDonald said while political life stateside is very contentious, she said an event like this is "really a gamechanger."
"The idea of an assassination attempt on any candidate for the presidency of the United States or any political candidate, I think is shocking and it gives us all pause for concern."
Ms McDonald said people who run for public office "have to be free to go about their campaigns safely."
"I would be sure that as fraught as political life is in the United States, that Democrats, Republicans, independents, everybody stands for square behind the idea that politics and democracy has to function and that means that campaigns have to be run and candidates have to have rallies and public events and to be safe."
