The Minister for Children Katherine Zappone has confirmed that the board of the new National Children's Hospital has appealed three of four conditions included in the fire safety certificate issued for the development by the Dublin Fire Brigade.
The new facility is being built on the St James's Hospital campus, and is due to open around 2021.
It will take over the services of the existing three Dublin children's hospitals: Our Lady's Children's Hospital in Crumlin; Temple Street Children's University Hospital in the city centre; and the National Children's Hospital at Tallaght.
Ms Zappone said the appeal to An Bord Pleanála was made "with an eye towards costs".
She said the primary responsibility and concern for her, Minister Harris and the hospital board is the safety of children but "at the same time they do have to have an eye in relation to the costs in terms of the hospital," and so they questioned whether or not the three conditions needed to be met.
The Minister said that whatever An Bord Pleanála decides on the conditions will be implemented by the hospital.
She added that she thinks people can be assured there will be proper fire safety standards in the hospital on that basis.
The minister was responding to a report in The Sunday Times that the Children's Hospital Board was appealing conditions including one concerning the extent of a sprinkler system.
In a statement released this afternoon, the board of the National Paediatric Hospital Development said: "The safety of children attending the new children's hospital and that of their parents and visitors, together with hospital staff and the wider community, is the primary concern for all those involved in this project.
"We are confident that the fire safety design measures we have proposed are both compliant with, and indeed exceed, current regulations and standards.
"The provision of fire sprinkler protection planned for the new children's hospital will exceed the number that is set out within the fire safety regulation legislation.