The Nursing and Midwifery Board has removed 2,258 nurses and midwives from the register, for not paying their annual registration fee.
The €100 fee is paid to stay on the register and once removed, it is an offence to practice nursing or midwifery.
Nurses can reapply to be registered and pay the fee.
The Board says it made the decision on 21 March in relation to the 2,258 nurses and midwives after renewal and reminder notices were sent to the nurses concerned and the fee was not paid.
The Minister for Health, Health Service Executive, known employers and the nurses and midwives have been notified in writing of the removals from the register.