The Minister for Health has said that scaremongers should butt out and leave medical advice on the HPV vaccine to medical professionals.
Simon Harris was speaking at the launch of a HSE campaign aimed encouraging parents to have their daughters vaccinated to help prevent cervical cancer.
Uptake of the vaccine is currently at an all time low, having dropped from about 90% originally to 50% last year.
The drop follows claims that a number of girls have suffered serious side effects from the injection.
"It is vital that we get the information out that this vaccine can save lives and prevent cancer," Mr Harris said.
"One of the most important things we can do is to provide accurate and credible information to enable parents to take a fully informed decision concerning HPV vaccination. We know that the HPV vaccine works and saves lives," he added.
The Director General of the Health Service Executive said the campaign against the vaccine is "emotional terrorism".
Tony O’Brien said there has been "a well orchestrated campaign, with no foundation" claiming the vaccine causes serious side effects.
HSE National Director of Health and Wellbeing Dr Stephanie O'Keeffe said the World Health Organisation and every national regulatory body in the world has found that the vaccine does not cause any of the alleged side effects.
She said 300 women are diagnosed with cervical cancer every year with 90 women dying from it.
The new campaign comes ahead of vaccine packs being issued to the parents of about 30,000 girls who have just started secondary school.
Speaking on RTÉ’s Morning Ireland, Professor Karina Butler, Chair of the National Immunisation Advisory Committee, said parents have been concerned about, temporarily associated with the vaccine, the development of chronic fatigue syndrome and chronic regional pain syndrome and another condition.
She said these are entities that occur in young people, especially girls, in that age group and the European Medicines Agency conducted a large study to see if there was any increased incidence among the vaccinated.
Prof Butler said: "And what they found was that the background rates were the same as those among the vaccinated children. There's been a subsequent follow-up review.
"In fact this vaccine has had more safety reviews, more formal safety reviews, than any other single vaccine; the latest from the WHO [World Health Organization] independent vaccine advisory group, and they concluded there was no reason to suspect any link between the vaccine and these conditions."
Dr Kevin Connolly, a retired Pediatrician and member of the NIAC, said "scare stories" and "unsubstantiated allegations" surrounding the vaccine is causing real harm and putting people at risk in developing preventable cancer.
Speaking on RTÉ’s Drivetime, he said if parents decide not to vaccinate their children it is putting them at risk.
He said studies have shown that the HPV vaccine prevents cervical cancer, adding that it is effective and safe.
