The Department of Health has been notified of 437 new cases and one further coronavirus-related death.
The number of people being treated for the virus in intensive care is up one to 46.
The Chief Medical Officer, in a statement, said it is important to remain vigilant and careful.
Dr Tony Holohan said: "As a country, we have now given a first dose of Covid-19 vaccine to 25% of eligible adults. In order to protect the vital work of the vaccination programme in offering us all protection from Covid-19, it is important we continue to remain vigilant and careful.
"Right now, we need to protect the progress we have made together.
"While we should remain cautious, we can also be cautiously optimistic. Our vaccination programme, alongside the continued commendable adherence of the vast majority of people in Ireland to the public health advice, are the key to exiting this pandemic in the coming months.
"However, doing things like mixing indoors when disease is still circulating at a high level puts our progress at risk. Please continue to act in the best interests of one another and be safe when socialising."
NPHET is not holding a public briefing this evening, but will make recommendations to Government on Wednesday.
It will meet that day before holding discussions later that evening with the Government's Cabinet Covid Committee.
This will be followed on Thursday by a full meeting of Cabinet where the expected easing of restrictions for May will be finalised.
The meeting will also set out a plan for continued reopening of society and the economy in June and July.
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Government sources described the decision by NPHET not to hold a briefing this evening as "the norm" on a week when a major Government announcement is due.
It is expected that Cabinet will agree this week to permit the reopening of all retail during May, beginning with click-and-collect services.
The full return of construction work, along with the reopening of hairdressers, is also set to happen during May.
Outdoor training for sports teams is likely to return next month too, while museums and galleries could reopen possibly sometime around 10 May.
Up to 50 people are likely to be permitted to attend regular church services next month but the numbers for weddings and funerals would remain capped at 25.
Hotels and guesthouses are set to reopen in June when it's possible the ban on inter-county travel would be lifted.
Outdoor dining is also set to return in June, however a minority of ministers still believe that could happen at some point in late May.
Indoor dining is set to remain off the menu of Government options until July.
The National Immunisation Advisory Committee (NIAC) is expected to recommend the use of the Johnson & Johnson vaccine for those aged 50 and older in Ireland.
However, it could also be used for younger people if there is no option of another vaccine, and for those who live in hard to reach communities.
The NIAC advice will be considered by the Chief Medical Officer, Dr Tony Holohan.
He will give his view and advice on it to the Minister for Health.
The Government will then advise the Health Service Executive on how it should proceed with the vaccine.
In a statement, the National Public Health Emergency Team said that the number of Covid-19 related deaths in Ireland now stands at 4,874, while the number of confirmed cases has risen to 247,069.
Of the new cases notified today, 220 are men and 216 are women. 76% are under the age of 45, while the average age is 29.
169 cases are in Dublin, 62 in Donegal, 40 in Kildare, 29 in Meath, 21 in Galway and the remaining 116 cases are spread across 17 other counties.
The 14-day incidence per 100,000 now stands at 121. The counties with the highest rate of incidence are Donegal (288.3), Kildare (209.9) and Offaly (191.1). The counties with the lowest rate of incidence are Kilkenny (26.2), Kerry (29.8) and Wexford (39.4).
NPHET said that as of Saturday 24 April, 1,385,753 Covid-19 vaccines have been administered in Ireland. 987,681 people have received their first dose of the vaccine, while 398,072 people have received their second vaccine dose.
Additional reporting Mícheál Lehane
