The Department of Health has been notified of 13 further deaths associated with Covid-19 and also reported 604 additional cases of the virus.
The number of people in ICU has increased by two to 66.
Of the deaths reported today, 12 occurred this month, and the median age of those who died was 77.
There has been a total of 4,666 deaths in Ireland due to Covid-19 and 234,541 confirmed cases of the virus.
Of the cases reported today, 299 are men and 298 are women; 77% are under 45 years of age and the median age is 27.
224 cases were in Dublin, 45 in Donegal, 36 in Kildare, 34 in Limerick, 26 in Tipperary and the remaining cases were spread across 20 other counties.
Meanwhile, more than three quarters of a million vaccines have been administered in Ireland, latest figures show.
Figures from the Health Service Executive show that as of 25 March, a total of 548,945 people have received a first dose, while 211,223 have received their second, meaning 760,168 vaccines have been administered here.
Health Minister Stephen Donnelly said on Twitter: "By the end of today we expect to have about 800,000 vaccines administered. On Wednesday and Thursday last week we had our biggest days in terms of vaccines administered. On average 1m+ vaccines a month will arrive in April, May and June and will be administered quickly."
Health Service Executive CEO Paul Reid said the vaccination programme is "heading to a new phase".
He wrote on Twitter that despite many frustrations in the first quarter "we've built a solid base".
The vaccination programme is heading to a new phase. This week there are well over 100K administered & close to 800K in total now done. Over 570K D1's, & 220K D2's (approx.15% & 6% of eligible population resp). Despite many frustrations in Q1, we've built a solid base. @HSELive— Paul Reid (@paulreiddublin) March 28, 2021
There has been an increase in the number of people being treated in hospital for Covid-19.
As of 8am, 322 patients were being treated in hospital for the virus, which is 18 more than the same time yesterday.
The figure compares to the peak of the third wave on 18 January, when 2,020 people were hospitalised.
The latest figures show that St James's Hospital, Beaumont and Connolly hospitals in Dublin are treating the largest number of people with the coronavirus.
COVID-19 Vaccines ????— COVID-19 Data Ireland (@COVID19DataIE) March 28, 2021
(Thursday / 25-03-21)
? First dose: 548,945 (+18,961)
? Second dose: 211,223 (+8,529)
? Total: 760,168 (+27,490)
? Pfizer: 576,519
? AZ: 157,029
? Moderna: 26,620
? % pop. with first dose: ~11%
? % pop. fully vaccinated: ~4.2%
Earlier, a specialist in infectious diseases said that a more sophisticated and centralised IT system needs to be established to track outbreaks and vaccine distribution.
Dr Cliona Ní Cheallaigh said a centralised computer system containing the medical details of all citizens should be fast-tracked to assist vaccination roll-out.
Speaking on RTÉ's Brendan O'Connor programme, she said that the resourcing of public health and population health specialities to do "backward tracking" and other services is another key part of the management plan.
She added that the importation of new virus variants, in particular the P1 variant from Brazil is of concern as the B117 variant is proving to be the "duracell bunny" of Covid variants.
Meanwhile, the deaths of two further people who previously tested positive for Covid-19 in Northern Ireland have been reported by the Department of Health.
Another 116 confirmed cases of the virus were also recorded in the last 24-hour reporting period.
This morning, there were 126 Covid-positive confirmed inpatients in hospital, of whom 15 were in ICUs.