It is understood that around 50 jobs are to be cut from Meta's recruitment division in Ireland.
It is the first wave in what could be a series of redundancies at the Irish operation of the social media giant.
The Taoiseach Leo Varadkar said his office had been informed of the Meta layoffs and that they would result in a "relatively small" number of redundancies.
Meta, the parent company of Facebook, Instagram and WhatsApp, announced yesterday that it is to cut around 10,000 jobs globally, just four months after it axed 11,000 workers.
Around 300 Irish-based jobs were lost as a result of the November announcement.
The company now employs around 2,600 people in Ireland.
Announcing the cuts yesterday, Meta CEO Mark Zuckerberg said that members of the recruitment division would be informed today if they are impacted.
Restructurings and layoffs will be announced in Meta's tech groups in late April and in business groups in late May.
A spokesperson for Meta Ireland said that the company had informed the Department of the Taoiseach about the changes to its recruitment team in Ireland.
The company said it would not be disclosing the number of job cuts at this time as there will be different stages in the redundancy process.
Mr Varadkar was asked about the latest redundancies at Meta at the start of his St Patrick's programme of engagements in Washington DC.
"We've received notification from Meta of a number of further job losses and I obviously want to extend my sympathies to those affected and to assure them that the Government is going to be there with them to make sure that they get the help they need in terms of income supports, or education and training opportunities, help to set up a new business if they want to, that's all going to be there," he said.
"I'm not going to put the number on it, but it is a relatively small number but it's up to Meta to talk to their own staff about that, it wouldn't be right for me to put a number on it today.
"I think what we're seeing across the tech sector is retrenchment. It's an industry that grew extremely fast, particularly during the pandemic period.
"Now what we are seeing in those companies is them sort of scaling back by about five or 10 percent. And that still means that a lot of tech companies are hiring, it still means that there are a lot of vacancies in the tech sector. And it still means that, in the medium to long term, I think we'll see these industries grow again."
Speaking to reporters in Washington, Mr Varadkar also addressed the fallout from Friday's collapse of the Silicon Valley Bank in the US - an institution that specialised in providing finance to tech firms.
The Taoiseach said the Irish government was monitoring the situation, but he insisted he did not have concerns about the Irish banking sector.
"We're certainly managing and monitoring the situation very closely," he said.
"But we're not concerned about the stability or health of any of our banks.
"There are a number of Irish tech companies that are affected by what's happening here.
"We are monitoring that extremely closely."
Additional reporting by PA
