150 jobs are to be created in counties Galway and Kildare by technology services and equipment producer Hewlett Packard Enterprise.
The new roles will be in research and development, cybersecurity, software development and cloud consulting.
The new staff will be recruited over the next two years and will be based out of its Ballybrit and Leixlip offices.
But the company says that its own technology will mean those who get the new positions will be able to work from anywhere in the country.
The firm has also decided to locate its European cyber security operations hub in Galway, where the specialty area has been under development for the past five years.
This will see new jobs for data scientists and incident response teams added.
HPE already employs 600 people in Ireland, which acts as a hub for its cloud and financial services.
"Ireland has an incredible technology-focused economy and a highly skilled workforce, and our investment in the country will further develop the country as a critical market for HPE's global business, as well as benefitting our customers, partners, team members and the citizens of Ireland," said Antonio Neri, President and CEO of Hewlett Packard Enterprise.
Hewlett Packard and its forerunners have been operating in Ireland for half a century.
The news was welcomed by the Government which has supported the investment through IDA Ireland.
CEO Martin Shanahan said the choice of Galway for HPE's European hub for cyber security operations is an important endorsement of Ireland's advanced technology ecosystem.
"This is a strategically important investment by HPE for Ireland and reflects the importance that the Galway and Leixlip sites play in the company's global business," he said.
HPE also has operations in Cork where its network solutions business, Aruba, has an office.
"Hewlett Packard Enterprise has been long-established in Ireland and is a significant source of employment in both Galway and Kildare," said the Tánaiste and Minister for Enterprise, Trade and Employment Leo Varadkar.
"This announcement demonstrates the company's continued commitment to our country and shows that we have the right infrastructure and ecosystem to enable leading technology companies to grow and thrive."
In 2015, Hewlett-Packard split into two companies, HP Inc and Hewlett Packard Enterprise in order to compete more effectively in the changing technology market.
County Kildare Chamber has welcomed the job announcement.
Allan Shine, CEO of the Chamber, said the new hi-tech jobs in the area of research and development, cybersecurity, software development and cloud consulting demonstrate that companies in the region can rely on our young talented workforce along with our excellent location.
"It strengthens our position as the leading region for foreign direct investment in Ireland," Mr Shine said.
"The new jobs further demonstrate that remote working will be a key component of new jobs coming out of Covid-19 as the hires will be able to work from any part of the country," he added.