Google chief executive Sundar Pichai will assume the CEO role at parent firm Alphabet in a shakeup at the top of the Silicon Valley titan.
Google co-founders Larry Page and Sergey Brin are stepping aside as leaders of the internet giant they founded 21 years ago.
The moves will end an extraordinary run that saw them build one of the world's most valuable and influential companies.
"While it has been a tremendous privilege to be deeply involved in the day-to-day management of the company for so long, we believe it's time to assume the role of proud parents - offering advice and love, but not daily nagging!" Page and Brin wrote in a blog post last night.
Page, Brin and Pichai have shared an emphasis on developing artificial intelligence software to make web searching faster and more personalised, while expanding the range of information and services available from a simple text query.
But their vision faces unprecedented scrutiny, with governments on five continents demanding better safeguards, an end to what many view as anti-competitive conduct, and more taxes from the world's largest online advertising company.
Google founders stepping down from management roles pic.twitter.com/xQ0vDAXVxF— RTÉ Business (@RTEbusiness) December 4, 2019
Thousands of employees have protested, and some have even resigned, over ongoing concern that Google's famous "don't be evil" mantra - once embraced by Page and Brin - may be cracking.
Streamlining Alphabet's unorthodox management structure could help the company better respond to the challenges and focus on growing profits, investors said.
Alphabet, which owns more than a dozen companies including self-driving car business Waymo and health care software company Verily, was created in 2015 as part of a restructuring.
The Google unit retained control of major businesses including video giant YouTube, the Android smartphone software and hardware operations, and cloud computing.
Page had wanted to focus on developing the newer businesses,which collectively lose money.
He left Google, by far the biggest and most profitable part of Alphabet, to Pichai, who in turn delegates a lot of authority to deputies who manage the various product lines.
Brin had stayed on as Alphabet's president, spending time on robotics, health ventures and other research projects.
But Page and Brin, once regular sights at public events and at Google headquarters, had become much less visible in recent years.
Page's retreat into the background drew increasing criticism from employees and US lawmakers, who demanded answers from him rather than Pichai about controversial projects such as an experimental search app for Chinese users.
Page and Brin, both 46, remain directors of the parent company but will cede their respective CEO and president titles immediately, Alphabet said.
The president role will not be filled, it said, describing the changes as long discussed.
Page's voice has been impaired for years because of a chronic condition, but his health did not play a role in the decision to step aside, Alphabet said.
"With Alphabet now well-established, and Google and the Other Bets operating effectively as independent companies, it's the natural time to simplify our management structure," the co-founders said.
"We are deeply committed to Google and Alphabet for the long term," the added.
The co-founders still control the company through their ownership of preferred shares.
As of April, Page held 26.1% of Alphabet's total voting power, Brin 25.25% and Pichai less than 1%.
Page and Brin developed the core Google search technology while they were still graduate students at Stanford, and it quickly proved far superior to competing search engines of the early Internet era.
By the time it went public in 2004, Google dominated websearch and was on its way to becoming a household name and the most powerful force in the global advertising business.
The young co-founders also nurtured a free-wheeling, engineering-driven culture that became a model in Silicon Valley, which is littered with startups launched by Google veterans.
He later led product development and engineering across all of Google's services for a year before gaining the CEO title.
Page and Brin are active in a range of non-Google ventures.
Page funded a company attempting to develop flying cars, and Brin at a conference last year discussed a budding interest in cryptocurrency.
The Alphabet structure was designed in part to let them pursue new "moonshot" projects.
Investors and regulators, however, were never completely sold.
Alphabet had used the separation between Page's and Pichai's roles to defend its limited financial disclosures about YouTube and other large Google businesses when the practice was questioned by US securities regulators in 2017.