A total of €43m is set to be invested in 26 research projects by Science Foundation Ireland.
The money, provided under the Investigators Programme, is aimed at helping some of the best researchers here to advance important studies in key areas.
These include inflammatory diseases, cancer, cattle breeding, communications, climate change and nanotechnology.
94 research jobs will be supported over the next five years by the programme.
It will also support links between the researchers and 20 different companies.
Six of the projects received co-funding from other research bodies like Teagasc, the Geological Survey of Ireland, the Marine Institute and the Environmental Protection Agency.
While 26 projects received funding, a further 33 were approved by the international peer-review panel as meeting the necessary standard and they may be funded later if budgets allow.
The institution whose researchers received the most grants was Trinity College Dublin, which secured nine.
Among the projects to receive funding is one by Professor James Gleeson from the University of Limerick, which will find ways to spread important information like terrorism and health alerts more quickly on social media.
Another project by Professor Paul Moynagh from Maynooth University will probe the causes of inflammatory diseases and try to develop new treatments.
In the area of food production, Professor Frank Wellmer from TCD's project will try to generate Brassica crops that are resistant to insects.
A day after the World Health Organisation warned the world is running out of antibiotics, a study by Professor Martin Caffrey, also from TCD, will try to develop new ones.