The Tánaiste and Minister for Foreign Affairs is in Washington DC for meetings with senior officials and members of the US Congress.
Simon Coveney is expected to discuss Northern Ireland, Brexit, immigration and foreign policy issues.
It comes amid growing concerns being expressed by some in the US about the impact of Brexit.
Yesterday, a group of prominent Irish-Americans wrote to Taoiseach Leo Varadkar and British Prime Minister Theresa May expressing alarm over the future of the Good Friday Agreement.
The group includes former members of Congress, former US Ambassadors to Ireland and the leaders of prominent Irish-American organisations.
Last week, a resolution was introduced in the US House of Representatives opposing the return of a hard border on the island of Ireland.
Irish-American Democratic Congressman Brendan Boyle was behind the move and said that now was the time for the US Congress to make it clear that it stands in strong opposition to a hard border.
The Irish-American lobby in Washington is taking a close interest in #Brexit. Former #US ambassador to Ireland, Kevin O'Malley, told @JulietteGash why. To listen back to the full interview, click here https://t.co/yGgLTGepPA pic.twitter.com/if2Fo1lRaa
— Morning Ireland (@morningireland) February 6, 2019
Speaking on RTÉ's Today with Sean O'Rourke, Mr Boyle said the US will not do anything to jeopardise its relationship with the European Union.
In what he termed a "reality check to Brexiteers", Mr Boyle said that the US was not going to negotiate any trade deal with the UK that would endanger existing deals with the EU.
Mr Boyle also said it would be naive of Britain to arrive on Capitol Hill in the hope of negotiating a deal if the Good Friday Agreement became collateral damage of Brexit.
"If you're about to start a negotiation but have just ripped up something that was negotiated and agreed to, that does not inspire confidence," he said.
Mr Boyle also said that domestic issues facing Theresa May, and her "inability to control her party", are "secondary to the issue of peace on the island of Ireland."
The Tánaiste @simoncoveney is meeting with fellow foreign ministers including @SecPompeo in the @StateDept in Washington. @rtenews pic.twitter.com/bMcvranuKh
— Brian O'Donovan (@BrianOD_News) February 6, 2019
Later today, Mr Coveney will meet members of Congress at a reception on Capitol Hill.
The event will mark the centenary of the first Dáil and the commencement of the 116th US Congress.
At the reception, the Tánaiste will launch the Irish Government's new strategy for the US and Canada.
He will also join fellow foreign ministers in Washington at a meeting of the Global Coalition to Defeat ISIS, of which Ireland is a member.
US President Donald Trump is due to address the event.
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