The Department of Agriculture has confirmed an outbreak of bird flu in a turkey flock in Co Laois.
The outbreak was identified last Friday.
It is understood the farm near Ballybrittas has up to 30,000 turkeys.
Restriction zones have been established around the affected holding, which includes a 3km protection zone and a 10km surveillance zone, in line with national and EU legislation.
Minister for Agriculture Martin Heydon said he wanted to express his sympathy with the flock owner concerned and with the other flock owners who have been impacted by outbreaks in recent weeks.
"This is a dynamic and evolving situation, particularly during the high-risk period for avian influenza and my department has moved swiftly to implement disease control measures in line with national and EU legislation," he said.
"Restriction zones have been established around the affected turkey premises, with strict movement controls on the movements of poultry and poultry products. Veterinary investigations and surveillance are ongoing."
A mandatory housing order for poultry and captive birds and a ban on gatherings of birds from different holdings was imposed on 10 November, in a bid to control the disease.
Read more: What is bird flu and how concerning is the spread?
"I want to thank all flock owners for their ongoing cooperation and for adhering to the biosecurity and housing regulations in place," Mr Heydon said.
"By working together, we can help protect our poultry sector during this challenging time" the Minister added."
The latest cases of bird flu follow confirmation earlier this month of three outbreaks on commercial turkey farms in the space of a week - in Monaghan, Meath, and Carlow.
Around 1.5 million turkeys are produced in Ireland for Christmas every year.
With roughly a week to go until the birds are prepared for this Christmas, officials said the risk to the food supply chain remains low.
Meanwhile, the risk to the public from the highly pathogenic strain of bird flu currently circulating is low and low-to-medium for occupationally exposed people, according to the HSE-HSPC.
There is no risk to food such as chicken or eggs, so long as they are prepared and cooked properly.
Anyone who comes across a dead or obviously sick bird is asked not to touch it and report the incident via the Department of Agriculture's Avian Check app.
