Trinity College students have set up an encampment near the Book of Kells, with the campus is closed to the public this evening.
Around 15 tents have been pitched on the grass near the entrance to the popular tourist attraction.
The protest - which includes dozens of students and a blockade of the Book of Kells - began shortly before 9pm.
Organisers say it is inspired by similar student protests in the US.
Trinity College Dublin Students' Union President László Molnárfi confirmed the protest and its reasons to RTÉ News, saying his and his colleagues want to see the immediate ending of business and academic connections between Trinity College and Israel.
He criticised Trinity College for what he said was a lack of a firm response to the war in Gaza, and said students will not be "intimidated" by the university.
In a post on X, Mr Molárfi wrote: "Students at Trinity College Dublin have set up an encampment for Palestine, demanding that their university cut ties with Israel as per BDS principles supported by the vast majority of students and staff."
Security on the gates only allowing staff and students with ID to enter the site.
A spokesperson for Trinity has been contacted to confirm why the campus is closed and the security measures are in place at its usually publicly open gates.

In a post on X, the Socialist Party said it was issuing an "urgent call of solidarity with students encampment for Gaza in Trinity College Dublin (at the Book of Kells)".
It issued a plea to "help secure Trinity College's student Gaza solidarity encampment".