The Health Service Executive has said all available monkeypox vaccine appointments have been fully booked.
It comes after 11 designated vaccination centres opened across the country today.
The HSE said that demand for the vaccine has been high and further appointments will be available at the start of next month.
Last week, the HSE said it intended on completing monkeypox vaccinations for high priority groups by the end of the year
The HSE estimates that between 6,000 and 13,000 people would benefit from a primary prevention monkeypox vaccine.
To date more than 2,000 vials of monkeypox vaccination have been sourced.
In August, the European Medicines Agency also advised that the vaccine could be administered intra-dermally, meaning vaccine vials can go further and provide more doses.
According to the EMA, one vial can provide five doses. In practice, the committee was told that vaccine administrators usually get four doses per vial.
Two doses of monkeypox vaccine are administered at least 28 days apart.
