RTÉ One's Claire Byrne Live programme will have its final show on Monday 30 May.
The weekly current affairs programme has been on air since 2015.
The programme, hosted by Claire Byrne, featured interviews, debates and a live studio audience.
Ms Byrne has previously spoken publicly of the challenge of presenting both a daily radio show and a late-night TV programme, and has now decided to focus on Today with Claire Byrne.
"When we started Claire Byrne Live in 2015, we wanted it to be a forum for people in Ireland to shape the news, respond to unfolding events and most importantly, to have their say," Ms Byrne said.
"We came through two general elections, two hugely significant referendums and one global pandemic in the time that we have been on air," she added.
Ms Byrne said she was "hugely proud" of the show and said she was "humbled to work with" the team and editors Aoife Stokes, Jane Murphy and Hugh Ormond.
"I have made the decision now to focus on my radio show and I am very much looking forward, in time, to working on other television projects for RTÉ," she added.
Jon Williams, Managing Director of RTÉ News & Current Affairs, paid tribute to Claire Byrne and the programme.
"For seven years, Claire has hosted Ireland's biggest conversation, giving the audience a voice on the key issues of the day," he said.
"From her extraordinary interview with the family of Clodagh Hawe, to the drama of the Leaders' Debates in two General Elections and breaking news throughout the pandemic, Claire Byrne Live has shown that current affairs can be both popular and engaging. I want to thank Claire for a truly remarkable run," he added.
Ms Byrne will continue to present Today with Claire Byrne on RTÉ Radio 1, Monday to Friday from 10am, and will also work with RTÉ on future television programmes.
RTÉ is currently developing ideas for a new programme to replace the series.