The Commission of Investigation into Mother and Baby Homes has found that a total of 734 children associated with the Regina Coeli hostel on Dublin's North Brunswick Street died, with the peak mortality being in the early 1940s.
The hostel accommodated 5,631 mothers and 5,434 children between 1930 and 1998. It was not run as a mother-and-baby home but took in women who were pregnant, as well as women with other problems who are not part of the commission's investigation.
As was the case with most of the mother-and-baby homes, 68% of infant deaths were during the 1940s.
The hostel was a former workhouse that was run by the Legion of Mary and was the only institution up until the 1970s where mothers were supported in their desire to raise their children. It also did not receive regular State support.
According to the report, it was preferred by many mothers as they could smoke, make tea and come and go freely.
Some women only stayed a couple of nights while others stayed for extended periods - one woman, who was admitted in 1955, gave birth to six children during the course of a 15-year stay.
However, living conditions were described as poor, with a staircase collapse in 1956 injuring a Legion of Mary volunteer. The building was condemned by Dublin Corporation in 1963.
"Reports of children suffering burns from boiling water, suggest that it had to be carried some distance, as opposed to flowing from a convenient tap, but Regina Coeli compensated for poor living conditions by enabling mothers to raise their children and giving them the freedom to come and go, not just to work, but for social occasions," the report states.
A report in 1948 claimed that infant mortality was three times the rate in Pelletstown - Saint Patrick's Mother and Baby home on Dublin's Navan Road - and that the hostel lacked "almost every proper facility in regard to both nursing and structure".
The commission said it did not prove feasible to establish cause of death from official records, as infant deaths occurred in 13 different hospitals and institutions.
It did establish there were 13 deaths among women at Regina Coeli, with the majority being before 1950.
Three were connected with pregnancy or childbirth, with the rest being due to infectious disease such as tuberculosis and bronchitis.