The United States has surpassed the grim milestone of 100,000 coronavirus deaths.
Confirmed US deaths just before 2200 GMT stood at 100,047, with 1.69 million infections, according to the tally compiled by Johns Hopkins University.
US House Speaker Nancy Pelosi paused during a news conference to note the staggering toll of the "villainous virus," even as states cautiously re-open their shuttered, devastated economies.
"Little did we know we would be coming here almost at the exact time when our country would be registering 100,000 people dying from the coronavirus," Ms Pelosi said.
Joe Biden, the Democratic Party's presumptive presidential nominee, noted the grisly landmark by speaking directly to suffering families.
"To those hurting, I'm so sorry for your loss," the former vice president said via tweet. "The nation grieves with you."
While many Western nations are creeping back toward some form of normality, the virus has continued its march in Latin America, which is outpacing Europe and the US in daily infections.
"We are particularly concerned that the number of new cases reported last week in Brazil was the highest for a seven-day period since the outbreak began," said Carissa Etienne, director of the Washington-based Pan American Health Organization.
"Both Peru and Chile are also reporting a high incidence, a sign that transmission is still accelerating in these countries."
Brazil reported the highest daily deaths in the world for the fifth straight day, pushing its toll to 24,512, with infections soaring to more than 390,000.
There are moments in our history so grim, so heart-rending, that they're forever fixed in each of our hearts as shared grief. Today is one of those moments. 100,000 lives have now been lost to this virus.— Joe Biden (@JoeBiden) May 27, 2020
To those hurting, I'm so sorry for your loss. The nation grieves with you. pic.twitter.com/SBBRKV4mPZ