Fine Gael has opened up an 11 point gap over Fianna Fáil according to the latest Sunday Business Post Red C opinion poll.
While support for Taoiseach Leo Varadkar's party dropped one point in the past three months, support for Fianna Fáil is down three points - with the party now at its lowest support levels in almost a year.
The poll shows support for Fine Gael is now at 33%, well ahead of Fianna Fáil on 22%.
Sinn Féin has also seen its rating drop, with the party down two points to 14%.
Support for independents is now up to 13%, a gain of four points since the last poll was conducted.
The Labour party is unchanged on 6%, while the Social Democrats, the Green Party and Solidarity-People Before Profit are all on 2%.
The Independent Alliance is on 4%, and Renua is on 1%.
The poll was taken in the seven days leading up to Thursday 13 September, which includes the period following the publication of Dr Gabriel Scally's report on the CervicalCheck controversy.
It involves a random sample of 1,000 adults, and compares to the last poll which was published on 20 May. The margin of error is plus or minus 3%.