Five people have died following a suspected explosion at and subsequent fire at an apartment block in Leicester.
Leicestershire Police say that five other people have also been taken to hospital, one of whom is in a critical condition.
A "search and rescue" operation begin this morning in the rubble of the shop and apartment that was destroyed in the blast.
Fire crews worked through the night, digging through rubble and battling the blaze after police declared a major incident last night.
Leicestershire Police said people may be still be missing following the incident, but the search has been temporarily halted at the site because of fears for the "structural integrity" of a neighbouring building.
Police Superintendent Shane O'Neill said: "The building consisted of a shop premises on the ground level and a two-storey flat above it.
"We believe there may be people who have not yet been accounted for and rescue efforts continue in order to locate any further casualties.
"Once the site is deemed to be safe, a joint investigation with Leicestershire Fire and Rescue Service will begin looking into the circumstances surrounding the incident, which at this stage is not being linked to terrorism."
Video taken at the scene on Hinckley Road shows flames billowing into the night sky as the fire engulfed what is believed to be a convenience store.
One clip appeared to show emergency services rushing to help someone close to flames that were visible from a distance.
The building appears to have stood next to a shop called TJ's Takeaway.
Andrew Brodie, the assistant chief fire officer for Leicestershire Fire and Rescue Service, tweeted that conditions were "arduous" for firefighters as they worked through a "bitterly cold night".
But he praised their "tremendous effort".
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Speaking to Sky News, Kat Pattinson, who lives on the same road as the fire, told how her "whole house shook" when the blast happened.
She added that the shop on fire is usually open until about 9pm on a Sunday, and has a flat above it.
Leicestershire Fire and Rescue said it began receiving calls from concerned members of the public at 7.03pm.
A spokeswoman said six fire engines had been requested and that the affected property was a two-floor building with a loft conversion that had suffered a "pancake collapse".
Police say an investigation will take place to establish the cause of the fire, but say there is currently no indication that it is terrorist-related.
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