A total of 17 Dublin Bus routes are to be diverted from College Green to allow the introduction of longer Cross City Luas trams.
The new arrangements will be in place from next Monday until An Bord Pleanála rules on council plans for a civic plaza in the area.
The restrictions follow discussions between the National Transport Authority (NTA), Dublin Bus and Dublin City Council.
The NTA has decided not to impose any restrictions on taxis but says this may be introduced if further restrictions are necessary.
It said the changes were necessary because commuters are experiencing delays in the College Green area.
Its believed that around 20% of bus routes going through College Green are affected.
Since the introduction of the Cross City Luas, it has been reported that pedestrians are having to wait three times as long to cross.
Some buses have also reported delays.
New longer 55-metre trams will start to be introduced over the coming weeks and it is felt that they will increase pressure on space.
The council had hoped to have the civic plaza in place and an end to east-west traffic movement through College Green that would include buses.
This plan is backed by the NTA but An Bord Pleanála is due to hold an oral hearing after objections from Dublin Bus and city centre businesses.
Dublin Bus said it welcomes the commitment by the council to provide bus priority measures to facilitate these route changes.
Dublin Chamber of Commerce has welcomed the plan.
The Chamber said the changes, which will see around one in five buses removed from College Green at peak times, will help reduce delays and improve inconsistent commute times for commuters.
Dublin Chamber's Head of Public Affairs Graeme McQueen said: "It was inevitable once the Luas trams started running through College Green that some changes may be needed to ensure all modes could move through the City Centre efficiently.
"There is no silver bullet that will solve all of the issues immediately, but the decision to remove some bus routes from College Green is necessary and will hopefully help improve commute times for those who rely on public transport to get to and from work," he added.
The details of the routes affected are as follows:
Some westbound and northbound routes servicing areas including Lucan, Adamstown, Blanchardstown, Ongar and Dunboyne Co Meath that currenty just pass through College Green will just have routes changed.
The 25, 25a, 25b, 25d, 37, 39, 39a and 70 currently go up College Street and around Westmoreland Street from Pearse Street but will be re-routed through Tara Street and Burgh Quay.
But some express commuter buses will have stops in College Green moved.
These are 25x, 27x, 32x, 33x, 39x, 41x, 51x, 66x and 67x, which only run at rush hour and mostly go through D'Olier Street, College Street and College Green.
They will be diverted through Hawkins Street, Townsend Street and Westland Row.
They mainly service the north of the city including Malahide, Clarehall, Skerries, Swords, Howth, Ongar, but also Lucan and Clondalkin, as well as Maynooth and Celbridge in Co Kildare.