The UN General Assembly has voted 128-9 to adopt a motion rejecting the US decision to recognise Jerusalem as the capital of Israel.
Ireland was one of the countries to vote in favour of the non-binding resolution, with 35 others abstaining and 21 countries not casting a vote.
US President Donald Trump had warned ahead of the vote in the 193-nation assembly that the US was "watching" and threatened reprisals against countries that back the measure.
Israel's envoy to the United Nations had vowed that his country would never be "driven" from Jerusalem.
Israeli Prime Minister Benjamin Netanyahu rejected the vote and thanked Mr Trump for his stance on Jerusalem.
"We reject the decision of the UN but we are satisfied by the high number of countries that didn't vote in favour of this decision," he said.
A spokesman for Palestinian President Mahmoud Abbas welcomed the vote, saying it was "a victory for Palestine".
He said: "This decision reaffirms once again that the just Palestinian cause enjoys the support of international law, and no decision by any party can change the reality.
"We will continue our efforts in the United Nations and at all international forums to put an end to this occupation and to establish our Palestinian state with east Jerusalem as its capital."
A draft resolution rejecting the US move was sent to the General Assembly after it was vetoed by the US at the Security Council on Monday, although all other 14 council members voted in favor.
The US cannot veto a general assembly resolution.
US Ambassador Nikki Haley warned of reprisals ahead of the vote, warning that "the United States will remember this day".
"This vote will make a difference on how Americans look at the UN and on how we look at countries who disrespect us in the UN," she told the UN General Assembly.
US & #Israel win support of Micronesia, Palau, Marshall Islands & Nauru in trying to block #UN #Jerusalem resolution. UK, #Ireland & most of #EU voted against #Trump pic.twitter.com/NH3kCBX8nW
— Jon Williams (@WilliamsJon) December 21, 2017
"We will remember it when we are called upon to once again make the world's largest contribution to the United Nations, and so many countries come calling on us, as they so often do, to pay even more and to use our influence for their benefit."
Earlier this month, Mr Trump reversed decades of US policy by announcing the United States recognised Jerusalem as the capital of Israel and would move its embassy there.
The status of Jerusalem is one of the thorniest obstacles to a peace deal between Israel and the Palestinians, who were furious over Mr Trump’s move.
The international community does not recognise Israeli sovereignty over the full city.
In a statement this evening, the Department of Foreign Affairs said: "Ireland voted today in favour of a resolution in the UN General Assembly on Jerusalem. This vote was in line with our established position on this issue. The vast majority of our EU partners voted in the same way.
"It has been the united position of the international community for decades, as set out in UN Security Council Resolutions, that a resolution of the Middle East conflict will include agreement for Jerusalem to be the capital of both Israel and the future state of Palestine.
"Ireland and the US share many core values, but there are occasionally issues on which we have different views. The status of Jerusalem is one such issue.
"We have no difficulty with our partners and friends having strong views and expressing them robustly, notwithstanding the fact that we may take a different view, as we do in this case."
