The death toll from a bombing at a shrine in southern Pakistan has risen to 52, with 105 injured, home minister for the southwestern Baluchistan province said.

"At least 52 people have been killed and some 105 others wounded," Sarfraz Bugti said.

The so-called Islamic State group has claimed a suicide bomber targeted the shrine, but the minister said it was not immediately clear if this was a suicide attack.

The blast occurred at the Shah Noorani shrine, located in Baluchistan province, about 100km north of the port city of Karachi.

It took place while hundreds of people were inside, said Hashim Ghalzai, a local district commissioner.

Provincial Home Minister Sarfaraz Bugti said 43 people were killed and Mr Ghalzai said more than 100 were wounded.

Wounded people were moved to the nearby town of Hub and to Karachi, rescue official Hakeem Nasi told Geo TV.

The government dispatched 25 ambulances from Hub to the shrine, said Akbar Harifal, provincial home secretary for Baluchistan.

"Every day, around sunset, there is a dhamaal (ritual dance) here, and there are large numbers of people who come for this," said Nawaz Ali, the shrine's custodian.

Baluchistan has seen some of the worst militant attacks this year in Pakistan, one of which was claimed by an Islamist movement that is allied to IS.

The attack comes months after Amjad Sabri, a renowned Sufi singer, was shot dead by two gunmen in Karachi in June.

Some observers have said that Mr Sabri may have been assassinated because he was a high-profile Sufi.

Sufism, a mystic Islamic order that believes in living saints, worships through music and is viewed as heretical by some hardline groups including the Taliban.

We need your consent to load this rte-player contentWe use rte-player to manage extra content that can set cookies on your device and collect data about your activity. Please review their details and accept them to load the content.Manage Preferences