A Palestinian fatally stabbed a 13-year-old Israeli girl in her bedroom in a settlement in the occupied West Bank.
Israeli guards in the settlement of Kiryat Arba shot the attacker dead and one member of the civilian armed response team was wounded, a military spokesman and a settler leader said.
The assailant was identified as a 19-year-old male from a nearby Palestinian village.
Prime Minister Benjamin Netanyahu said his home would be destroyed and permits enabling his relatives to work in Israel revoked.
Mr Netanyahu called on Palestinian leaders to condemn the attack and take immediate steps to stop what he described as incitement that Israel has cited as a main factor behind a string of assaults over the last nine months.
"The horrific murder of an innocent girl in her bed sheds light on the bloodlust and lack of humanity displayed by the terrorists we are facing," he said.
Malachi Levinger, chairman of Kiryat Arba's governing council, said the assailant climbed a security fence and entered a home where he attacked Hallel Yaffa Ariel.
In Washington, the State Department confirmed the teenager was a US citizen. "This brutal act of terrorism is simply unconscionable," said spokesman John Kirby.
