Minister for Jobs, Enterprise and Innovation Richard Bruton has said that ending the so-called "double Irish" has not been an issue for US companies.
The minister is the first member of the Government to meet companies in the US following the changes announced in the Budget earlier this month, including the abolition of the "double Irish" tax scheme.
Speaking in Washington DC on a five-day trade mission, Mr Bruton said the business people he had met had welcomed Ireland's move to get ahead of the changing international tax environment by taking decisive action.
He said that the Budget announcements had given certainty to the situation and that this had been viewed positively by US companies with businesses in Ireland, and those considering a move.
He said companies were welcoming the introduction of the Knowledge Development Box - an innovation "box" that would allow foreign companies to build their new products and services and to use Ireland as a place to grow their businesses.
Mr Bruton said it was important that this new regime was designed in a way that would promote innovation as well as giving "best in class" to companies who want to invest in Ireland.
A consultation is under way at the moment, led by Minister for Finance Michael Noonan.
During the trade mission to the US, Mr Bruton will visit four cities and meet 17 companies operating in the financial services, healthcare and IT sectors.
The companies he is meeting include a mix of those with existing operations in Ireland and those interested in locating here.
Meanwhile, the senior vice president of the world's largest education technology company has said that the tax regime in Ireland had no impact on its decision to begin operations in Dublin.
Mark Jones, Chief Product Officer for Ellucian, said that they acquired an Irish company - Campus IT - because it was a good fit for their existing business.
He was speaking at the company's headquarters in Virginia in the United States ahead of meeting with Mr Bruton.
Mr Jones said that the company had been surprised by the "work ethic and spirit of innovation" that they had found in Ireland.
He said Ellucian had found Ireland to be a "very inviting country", where the people had a "tremendous spirit of innovation" and a "willingness to work" who could also see the "broader global picture".
He also said that Dublin was "a great place" to find developer and software talent.
Ellucian took over Dublin-based company Campus IT in January of this year.
The Irish company was a provider of student management systems for higher education institutions in Ireland and in the UK.
Ellucian is the largest provider of technology solutions for higher level education in the world, and works with 2,400 education institutions in over 40 countries.